Acral lentiginous melanoma mimicking benign disease: The Emory experience

Seaver L. Soon, Alvin Jr Solomon, Diamondis Papadopoulos, Douglas R. Murray, Barbara McAlpine, Carl V. Washington

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Background: Plantar and subungual melanoma exhibits a higher misdiagnosis rate relative to other anatomic sites. Misdiagnosis and delay in diagnosis are statistically associated with poorer patient outcome. Awareness of atypical presentations of acral melanoma may, thus, be important to decrease misdiagnosis rates and improve patient outcome. Methods: We conducted a retrospective case review of plantar or lower-extremity subungual melanoma performed at Winship Cancer Center, a tertiary care, referral center affiliated with Emory University, between 1985 and 2001. Results: A total of 53 cases of plantar or lower-extremity subungual melanoma were identified. Of 53 cases with a final diagnosis of melanoma, 18 were initially misdiagnosed. Misdiagnoses included wart, callous, fungal disorder, foreign body, crusty lesion, sweat gland condition, blister, nonhealing wound, mole, keratoacanthoma, subungual hematoma, onychomycosis, ingrown toenail, and defective/infected toenail. Of the 18 misdiagnosed cases, 9 were clinically amelanotic. Conclusion: Awareness that amelanotic variants of acral melanoma may assume the morphology of benign hyperkeratotic dermatoses may increase the rate of correct diagnosis and improve patient outcome.

Original languageEnglish (US)
Pages (from-to)183-188
Number of pages6
JournalJournal of the American Academy of Dermatology
Volume48
Issue number2 SUPPL.
DOIs
StatePublished - Feb 1 2003
Externally publishedYes

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Diagnostic Errors
Melanoma
Extremities
Nails
Tertiary Care Centers
Lower Extremity
Keratoacanthoma
Onychomycosis
Sweat Glands
Warts
Blister
Foreign Bodies
Skin Diseases
Hematoma
Wounds and Injuries
Neoplasms

ASJC Scopus subject areas

  • Dermatology

Cite this

Soon, S. L., Solomon, A. J., Papadopoulos, D., Murray, D. R., McAlpine, B., & Washington, C. V. (2003). Acral lentiginous melanoma mimicking benign disease: The Emory experience. Journal of the American Academy of Dermatology, 48(2 SUPPL.), 183-188. https://doi.org/10.1067/mjd.2003.63

Acral lentiginous melanoma mimicking benign disease : The Emory experience. / Soon, Seaver L.; Solomon, Alvin Jr; Papadopoulos, Diamondis; Murray, Douglas R.; McAlpine, Barbara; Washington, Carl V.

In: Journal of the American Academy of Dermatology, Vol. 48, No. 2 SUPPL., 01.02.2003, p. 183-188.

Research output: Contribution to journalArticle

Soon, SL, Solomon, AJ, Papadopoulos, D, Murray, DR, McAlpine, B & Washington, CV 2003, 'Acral lentiginous melanoma mimicking benign disease: The Emory experience', Journal of the American Academy of Dermatology, vol. 48, no. 2 SUPPL., pp. 183-188. https://doi.org/10.1067/mjd.2003.63
Soon SL, Solomon AJ, Papadopoulos D, Murray DR, McAlpine B, Washington CV. Acral lentiginous melanoma mimicking benign disease: The Emory experience. Journal of the American Academy of Dermatology. 2003 Feb 1;48(2 SUPPL.):183-188. https://doi.org/10.1067/mjd.2003.63
Soon, Seaver L. ; Solomon, Alvin Jr ; Papadopoulos, Diamondis ; Murray, Douglas R. ; McAlpine, Barbara ; Washington, Carl V. / Acral lentiginous melanoma mimicking benign disease : The Emory experience. In: Journal of the American Academy of Dermatology. 2003 ; Vol. 48, No. 2 SUPPL. pp. 183-188.
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