Acquired Heterochromia with Homer Syndrome in Two Adults

Michael C. Diesenhouse, David A. Palay, Nancy J. Newman, King To, Daniel Albert

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Background: Heterochromia iridis, asymmetry of iris pigmentation, has been well described with congenital Horner syndrome. Acquired heterochromia associated with lesions in the ocular sympathetic pathways in adulthood, however, is rare. Methods: Two cases are reported in which sympathectomy in adults resulted in ipsilateral Horner syndrome with heterochromia. In each case, pharmacologic testing with cocaine and hydroxyamphetamine was performed. Results: In both cases, sympathectomy occurred at the level of the second order neuron, but hydroxyamphetamine testing suggested at least partial third order neuron involvement. Conclusion: Acquired heterochromia can occur in adults. The partial response to hydroxyamphetamine in the two cases presented may reflect trans-synaptic degeneration of the postganglionic neuron. A reduction in trophic influences on iris melanocytes may have contributed to the observed heterochromia.

Original languageEnglish (US)
Pages (from-to)1815-1817
Number of pages3
JournalOphthalmology
Volume99
Issue number12
DOIs
StatePublished - Jan 1 1992
Externally publishedYes

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p-Hydroxyamphetamine
Sympathectomy
Iris
Neurons
Retrograde Degeneration
Horner Syndrome
Melanocytes
Pigmentation
Cocaine

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Diesenhouse, M. C., Palay, D. A., Newman, N. J., To, K., & Albert, D. (1992). Acquired Heterochromia with Homer Syndrome in Two Adults. Ophthalmology, 99(12), 1815-1817. https://doi.org/10.1016/S0161-6420(92)31720-8

Acquired Heterochromia with Homer Syndrome in Two Adults. / Diesenhouse, Michael C.; Palay, David A.; Newman, Nancy J.; To, King; Albert, Daniel.

In: Ophthalmology, Vol. 99, No. 12, 01.01.1992, p. 1815-1817.

Research output: Contribution to journalArticle

Diesenhouse, MC, Palay, DA, Newman, NJ, To, K & Albert, D 1992, 'Acquired Heterochromia with Homer Syndrome in Two Adults', Ophthalmology, vol. 99, no. 12, pp. 1815-1817. https://doi.org/10.1016/S0161-6420(92)31720-8
Diesenhouse, Michael C. ; Palay, David A. ; Newman, Nancy J. ; To, King ; Albert, Daniel. / Acquired Heterochromia with Homer Syndrome in Two Adults. In: Ophthalmology. 1992 ; Vol. 99, No. 12. pp. 1815-1817.
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