Acoustically modulated speckle imaging of biological tissues

Steven L. Jacques, Sean J. Kirkpatrick

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


A video laser speckle imaging technique yields images with contrast based on the mechanical properties of a tissue. Fluctuations of laser speckle patterns induced by acoustically driving the tissue at various frequencies in the 0-30-Hz range encode the mechanical strain of the tissue. At each acoustic frequency and within the camera acquisition time, each camera pixel integrates a temporally fluctuating speckle intensity whose variance encodes the mechanical strain in response to the acoustic modulation. The magnitude and the frequency dependence of this strain provide mechanical information about the tissue and are the contrast mechanism for images.

Original languageEnglish (US)
Pages (from-to)879-881
Number of pages3
JournalOptics Letters
Issue number11
StatePublished - Jun 1 1998

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics


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