Acoustic droplet vaporization and propulsion of perfluorocarbon-loaded microbullets for targeted tissue penetration and deformation

Daniel Kagan, Michael J. Benchimol, Jonathan C. Claussen, Erdembileg Chuluun-Erdene, Sadik Esener, Joseph Wang

Research output: Contribution to journalArticle

148 Scopus citations

Abstract

Bullets and rockets: Ultrasound-triggered vaporization of a perfluorocarbon compound loaded into microbullets provides the necessary force for the microbullets to penetrate, cleave, and deform cellular tissue for potential targeted drug delivery and precision nanosurgery. The microbullets have an inner Au layer that allows conjugation of a monolayer of thiolated cysteamine (green in picture) for electrostatic attachment of perfluorocarbon droplets (purple droplets).

Original languageEnglish (US)
Pages (from-to)7519-7522
Number of pages4
JournalAngewandte Chemie - International Edition
Volume51
Issue number30
DOIs
StatePublished - Jul 23 2012
Externally publishedYes

Keywords

  • drug delivery
  • electrostatic interactions
  • perfluorinated solvents
  • ultrasound
  • vaporization

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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