Acetylcholine release in ventral tegmental area by hypothalamic self- stimulation, eating, and drinking

Pedro V. Rada, Gregory Mark, John J. Yeomans, Bartley G. Hoebel

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

Evidence is presented for an acetylcholine (ACh) input to the midbrain ventral tegmental area (VTA) as part of a system for self-stimulation and ingestive behavior. Male rats were prepared with an electrode in the perifornical lateral hypothalamus and an ipsilateral guideshaft for microdialysis in the VTA. Extracellular ACh increased in the VTA during self- stimulation, auto-stimulation, eating, or drinking. Infusion of atropine into the VTA via the microdialysis probe was sufficient to stop self-stimulation and reduce intake of food. It is concluded that ACh acts at muscarinic receptors in the VTA as part of a circuit that modulates hypothalamic self- stimulation and ingestive behavior. (C) 2000 Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)375-379
Number of pages5
JournalPharmacology Biochemistry and Behavior
Volume65
Issue number3
DOIs
StatePublished - Mar 2000

Fingerprint

Self Stimulation
Ventral Tegmental Area
Drinking
Acetylcholine
Eating
Microdialysis
Muscarinic Receptors
Atropine
Rats
Lateral Hypothalamic Area
Mesencephalon
Electrodes
Networks (circuits)

Keywords

  • Acetylcholine release
  • Drinking
  • Eating
  • Self-stimulation
  • Ventral tegmental area

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Cite this

Acetylcholine release in ventral tegmental area by hypothalamic self- stimulation, eating, and drinking. / Rada, Pedro V.; Mark, Gregory; Yeomans, John J.; Hoebel, Bartley G.

In: Pharmacology Biochemistry and Behavior, Vol. 65, No. 3, 03.2000, p. 375-379.

Research output: Contribution to journalArticle

Rada, Pedro V. ; Mark, Gregory ; Yeomans, John J. ; Hoebel, Bartley G. / Acetylcholine release in ventral tegmental area by hypothalamic self- stimulation, eating, and drinking. In: Pharmacology Biochemistry and Behavior. 2000 ; Vol. 65, No. 3. pp. 375-379.
@article{35a9121f94b544bfbef034b54839d9e2,
title = "Acetylcholine release in ventral tegmental area by hypothalamic self- stimulation, eating, and drinking",
abstract = "Evidence is presented for an acetylcholine (ACh) input to the midbrain ventral tegmental area (VTA) as part of a system for self-stimulation and ingestive behavior. Male rats were prepared with an electrode in the perifornical lateral hypothalamus and an ipsilateral guideshaft for microdialysis in the VTA. Extracellular ACh increased in the VTA during self- stimulation, auto-stimulation, eating, or drinking. Infusion of atropine into the VTA via the microdialysis probe was sufficient to stop self-stimulation and reduce intake of food. It is concluded that ACh acts at muscarinic receptors in the VTA as part of a circuit that modulates hypothalamic self- stimulation and ingestive behavior. (C) 2000 Elsevier Science Inc.",
keywords = "Acetylcholine release, Drinking, Eating, Self-stimulation, Ventral tegmental area",
author = "Rada, {Pedro V.} and Gregory Mark and Yeomans, {John J.} and Hoebel, {Bartley G.}",
year = "2000",
month = "3",
doi = "10.1016/S0091-3057(99)00218-X",
language = "English (US)",
volume = "65",
pages = "375--379",
journal = "Pharmacology Biochemistry and Behavior",
issn = "0091-3057",
publisher = "Elsevier Inc.",
number = "3",

}

TY - JOUR

T1 - Acetylcholine release in ventral tegmental area by hypothalamic self- stimulation, eating, and drinking

AU - Rada, Pedro V.

AU - Mark, Gregory

AU - Yeomans, John J.

AU - Hoebel, Bartley G.

PY - 2000/3

Y1 - 2000/3

N2 - Evidence is presented for an acetylcholine (ACh) input to the midbrain ventral tegmental area (VTA) as part of a system for self-stimulation and ingestive behavior. Male rats were prepared with an electrode in the perifornical lateral hypothalamus and an ipsilateral guideshaft for microdialysis in the VTA. Extracellular ACh increased in the VTA during self- stimulation, auto-stimulation, eating, or drinking. Infusion of atropine into the VTA via the microdialysis probe was sufficient to stop self-stimulation and reduce intake of food. It is concluded that ACh acts at muscarinic receptors in the VTA as part of a circuit that modulates hypothalamic self- stimulation and ingestive behavior. (C) 2000 Elsevier Science Inc.

AB - Evidence is presented for an acetylcholine (ACh) input to the midbrain ventral tegmental area (VTA) as part of a system for self-stimulation and ingestive behavior. Male rats were prepared with an electrode in the perifornical lateral hypothalamus and an ipsilateral guideshaft for microdialysis in the VTA. Extracellular ACh increased in the VTA during self- stimulation, auto-stimulation, eating, or drinking. Infusion of atropine into the VTA via the microdialysis probe was sufficient to stop self-stimulation and reduce intake of food. It is concluded that ACh acts at muscarinic receptors in the VTA as part of a circuit that modulates hypothalamic self- stimulation and ingestive behavior. (C) 2000 Elsevier Science Inc.

KW - Acetylcholine release

KW - Drinking

KW - Eating

KW - Self-stimulation

KW - Ventral tegmental area

UR - http://www.scopus.com/inward/record.url?scp=0033984456&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033984456&partnerID=8YFLogxK

U2 - 10.1016/S0091-3057(99)00218-X

DO - 10.1016/S0091-3057(99)00218-X

M3 - Article

VL - 65

SP - 375

EP - 379

JO - Pharmacology Biochemistry and Behavior

JF - Pharmacology Biochemistry and Behavior

SN - 0091-3057

IS - 3

ER -