Accurate and cost-effective evaluation of breast masses in males

John Vetto, Waldemar Schmidt, Rodney Pommier, John Ditomasso, Heidi Eppich, William Wood, Dane Moseson

    Research output: Contribution to journalArticle

    36 Citations (Scopus)

    Abstract

    BACKGROUND: Because the majority of breast masses in males are benign and need not be excised if asymptomatic, we studied the combination of physical examination (PE) and fine needle aspiration (FNA), with or without mammography, as a diagnostic alternative to routine surgical biopsy of these lesions. METHODS: A diagnostic test study and cost-effectiveness analysis was performed in three participating multidisciplinary breast clinics, involving a consecutive sample of 51 males with unilateral breast masses. Each lesion was tested with both PE and FNA; 13 were also studied with mammography, and each test was scored as benign or suspicious. Lesions for which all tests were benign were followed up clinically (mean 19 months). Lesions for which any test was suspicious were excised. RESULTS: All tests were benign in 38 cases. No cancers developed at the index sites during follow-up of these lesions, including 8 excisional biopsies done for symptoms (negative predictive value and specificity 100%). Open biopsy confirmed malignancy in all 6 cases for which all tests were suspicious (positive predictive value and sensitivity 100%). In all 7 cases where the tests were not in agreement, open biopsy was benign. In these cases FNA (2 false positives) proved more accurate than PE (5 false positives). Mammography added no additional diagnostic information to the combination of PE and FNA. Compared with routine open biopsy, the combination of PE and FNA avoided surgical biopsy in 30 of the 51 lesions, and was associated with an average decrease in charges of up to $510 per case. CONCLUSIONS: The combination of PE and FNA for the evaluation of breast masses in males is diagnostically accurate and results in a reduction in patient charges compared with routine open biopsy.

    Original languageEnglish (US)
    Pages (from-to)383-387
    Number of pages5
    JournalAmerican Journal of Surgery
    Volume175
    Issue number5
    DOIs
    StatePublished - 1998

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    Fine Needle Biopsy
    Breast
    Physical Examination
    Biopsy
    Costs and Cost Analysis
    Mammography
    Routine Diagnostic Tests
    Cost-Benefit Analysis
    Neoplasms

    ASJC Scopus subject areas

    • Surgery

    Cite this

    Accurate and cost-effective evaluation of breast masses in males. / Vetto, John; Schmidt, Waldemar; Pommier, Rodney; Ditomasso, John; Eppich, Heidi; Wood, William; Moseson, Dane.

    In: American Journal of Surgery, Vol. 175, No. 5, 1998, p. 383-387.

    Research output: Contribution to journalArticle

    Vetto, John ; Schmidt, Waldemar ; Pommier, Rodney ; Ditomasso, John ; Eppich, Heidi ; Wood, William ; Moseson, Dane. / Accurate and cost-effective evaluation of breast masses in males. In: American Journal of Surgery. 1998 ; Vol. 175, No. 5. pp. 383-387.
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    abstract = "BACKGROUND: Because the majority of breast masses in males are benign and need not be excised if asymptomatic, we studied the combination of physical examination (PE) and fine needle aspiration (FNA), with or without mammography, as a diagnostic alternative to routine surgical biopsy of these lesions. METHODS: A diagnostic test study and cost-effectiveness analysis was performed in three participating multidisciplinary breast clinics, involving a consecutive sample of 51 males with unilateral breast masses. Each lesion was tested with both PE and FNA; 13 were also studied with mammography, and each test was scored as benign or suspicious. Lesions for which all tests were benign were followed up clinically (mean 19 months). Lesions for which any test was suspicious were excised. RESULTS: All tests were benign in 38 cases. No cancers developed at the index sites during follow-up of these lesions, including 8 excisional biopsies done for symptoms (negative predictive value and specificity 100{\%}). Open biopsy confirmed malignancy in all 6 cases for which all tests were suspicious (positive predictive value and sensitivity 100{\%}). In all 7 cases where the tests were not in agreement, open biopsy was benign. In these cases FNA (2 false positives) proved more accurate than PE (5 false positives). Mammography added no additional diagnostic information to the combination of PE and FNA. Compared with routine open biopsy, the combination of PE and FNA avoided surgical biopsy in 30 of the 51 lesions, and was associated with an average decrease in charges of up to $510 per case. CONCLUSIONS: The combination of PE and FNA for the evaluation of breast masses in males is diagnostically accurate and results in a reduction in patient charges compared with routine open biopsy.",
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    AU - Wood, William

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