Accuracy, repeatability, and interplatform reproducibility of T₁ quantification methods used for DCE-MRI: Results from a multicenter phantom study

Purpose: To determine the in vitro accuracy, test-retest repeatability, and interplatform reproducibility of T₁ quantification protocols used for dynamic contrast-enhanced MRI at 1.5 and 3 T. Methods: A T₁ phantom with 14 samples was imaged at eight centers with a common inversion-recovery spin-echo (IR-SE) protocol and a variable flip angle (VFA) protocol using seven flip angles, as well as site-specific protocols (VFA with different flip angles, variable repetition time, proton density, and Look-Locker inversion recovery). Factors influencing the accuracy (deviation from reference NMR T₁ measurements) and repeatability were assessed using general linear mixed models. Interplatform reproducibility was assessed using coefficients of variation. Results: For the common IR-SE protocol, accuracy (median error across platforms = 1.4–5.5%) was influenced predominantly by T₁ sample (P < 10⁻⁶), whereas test-retest repeatability (median error = 0.2–8.3%) was influenced by the scanner (P < 10⁻⁶). For the common VFA protocol, accuracy (median error = 5.7–32.2%) was influenced by field strength (P = 0.006), whereas repeatability (median error = 0.7–25.8%) was influenced by the scanner (P < 0.0001). Interplatform reproducibility with the common VFA was lower at 3 T than 1.5 T (P = 0.004), and lower than that of the common IR-SE protocol (coefficient of variation 1.5T: VFA/IR-SE = 11.13%/8.21%, P = 0.028; 3 T: VFA/IR-SE = 22.87%/5.46%, P = 0.001). Among the site-specific protocols, Look-Locker inversion recovery and VFA (2–3 flip angles) protocols showed the best accuracy and repeatability (errors < 15%). Conclusions: The VFA protocols with 2 to 3 flip angles optimized for different applications achieved acceptable balance of extensive spatial coverage, accuracy, and repeatability in T₁ quantification (errors < 15%). Further optimization in terms of flip-angle choice for each tissue application, and the use of B₁ correction, are needed to improve the robustness of VFA protocols for T₁ mapping. Magn Reson Med 79:2564–2575, 2018.