Accuracy of screening mammography varies by week of menstrual cycle

Diana L. Miglioretti, Rod Walker, Donald L. Weaver, Diana S M Buist, Stephen H. Taplin, Patricia (Patty) Carney, Robert D. Rosenberg, Mark B. Dignan, Zhuo Zhang, Emily White

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Purpose: To investigate sensitivity, specificity, and cancer detection rate of screening mammography according to week of menstrual cycle among premenopausal women. Materials and Methods: In this institutional review board - approved HIPAA-compliant study, sensitivity, specificity, and cancer detection rate of 387 218 screening mammograms linked to 1283 breast cancers in premenopausal women according to week of menstrual cycle were studied by using prospectively collected information from the Breast Cancer Surveillance Consortium. Logistic regression analysis was used to test for differences in mammography performance according to week of menstrual cycle, adjusting for age and registry. Results: Overall, screening mammography performance did not differ according to week of menstrual cycle. However, when analyses were subdivided according to prior mammography, different patterns emerged. For the 66.6% of women who had undergone regular screening (mammography had been performed within the past 2 years), sensitivity was higher in week 1 (79.5% ) than in subsequent weeks (week 2, 70.3%; week 3, 67.4%; week 4, 73.0%; P = .041). In the 17.8% of women who underwent mammography for the first time in this study, sensitivity tended to be lower during the follicular phase (week 1, 72.1%; week 2, 80.4%; week 3, 84.6%; week 4, 93.8%; P =.051). Sensitivity did not vary significantly by week in menstrual cycle in women who had undergone mammography more than 3 years earlier. There were no clinically meaningful differences in specificity or cancer detection rate. Conclusion: Premenopausal women who undergo regular screening may benefit from higher sensitivity of mammography if they schedule screening mammography during the 1st week of their menstrual cycle.

Original languageEnglish (US)
Pages (from-to)372-379
Number of pages8
JournalRadiology
Volume258
Issue number2
DOIs
StatePublished - Feb 2011

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Mammography
Menstrual Cycle
Breast Neoplasms
Health Insurance Portability and Accountability Act
Sensitivity and Specificity
Neoplasms
Follicular Phase
Research Ethics Committees
Registries
Appointments and Schedules
Logistic Models
Regression Analysis

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Miglioretti, D. L., Walker, R., Weaver, D. L., Buist, D. S. M., Taplin, S. H., Carney, P. P., ... White, E. (2011). Accuracy of screening mammography varies by week of menstrual cycle. Radiology, 258(2), 372-379. https://doi.org/10.1148/radiol.10100974

Accuracy of screening mammography varies by week of menstrual cycle. / Miglioretti, Diana L.; Walker, Rod; Weaver, Donald L.; Buist, Diana S M; Taplin, Stephen H.; Carney, Patricia (Patty); Rosenberg, Robert D.; Dignan, Mark B.; Zhang, Zhuo; White, Emily.

In: Radiology, Vol. 258, No. 2, 02.2011, p. 372-379.

Research output: Contribution to journalArticle

Miglioretti, DL, Walker, R, Weaver, DL, Buist, DSM, Taplin, SH, Carney, PP, Rosenberg, RD, Dignan, MB, Zhang, Z & White, E 2011, 'Accuracy of screening mammography varies by week of menstrual cycle', Radiology, vol. 258, no. 2, pp. 372-379. https://doi.org/10.1148/radiol.10100974
Miglioretti DL, Walker R, Weaver DL, Buist DSM, Taplin SH, Carney PP et al. Accuracy of screening mammography varies by week of menstrual cycle. Radiology. 2011 Feb;258(2):372-379. https://doi.org/10.1148/radiol.10100974
Miglioretti, Diana L. ; Walker, Rod ; Weaver, Donald L. ; Buist, Diana S M ; Taplin, Stephen H. ; Carney, Patricia (Patty) ; Rosenberg, Robert D. ; Dignan, Mark B. ; Zhang, Zhuo ; White, Emily. / Accuracy of screening mammography varies by week of menstrual cycle. In: Radiology. 2011 ; Vol. 258, No. 2. pp. 372-379.
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abstract = "Purpose: To investigate sensitivity, specificity, and cancer detection rate of screening mammography according to week of menstrual cycle among premenopausal women. Materials and Methods: In this institutional review board - approved HIPAA-compliant study, sensitivity, specificity, and cancer detection rate of 387 218 screening mammograms linked to 1283 breast cancers in premenopausal women according to week of menstrual cycle were studied by using prospectively collected information from the Breast Cancer Surveillance Consortium. Logistic regression analysis was used to test for differences in mammography performance according to week of menstrual cycle, adjusting for age and registry. Results: Overall, screening mammography performance did not differ according to week of menstrual cycle. However, when analyses were subdivided according to prior mammography, different patterns emerged. For the 66.6{\%} of women who had undergone regular screening (mammography had been performed within the past 2 years), sensitivity was higher in week 1 (79.5{\%} ) than in subsequent weeks (week 2, 70.3{\%}; week 3, 67.4{\%}; week 4, 73.0{\%}; P = .041). In the 17.8{\%} of women who underwent mammography for the first time in this study, sensitivity tended to be lower during the follicular phase (week 1, 72.1{\%}; week 2, 80.4{\%}; week 3, 84.6{\%}; week 4, 93.8{\%}; P =.051). Sensitivity did not vary significantly by week in menstrual cycle in women who had undergone mammography more than 3 years earlier. There were no clinically meaningful differences in specificity or cancer detection rate. Conclusion: Premenopausal women who undergo regular screening may benefit from higher sensitivity of mammography if they schedule screening mammography during the 1st week of their menstrual cycle.",
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N2 - Purpose: To investigate sensitivity, specificity, and cancer detection rate of screening mammography according to week of menstrual cycle among premenopausal women. Materials and Methods: In this institutional review board - approved HIPAA-compliant study, sensitivity, specificity, and cancer detection rate of 387 218 screening mammograms linked to 1283 breast cancers in premenopausal women according to week of menstrual cycle were studied by using prospectively collected information from the Breast Cancer Surveillance Consortium. Logistic regression analysis was used to test for differences in mammography performance according to week of menstrual cycle, adjusting for age and registry. Results: Overall, screening mammography performance did not differ according to week of menstrual cycle. However, when analyses were subdivided according to prior mammography, different patterns emerged. For the 66.6% of women who had undergone regular screening (mammography had been performed within the past 2 years), sensitivity was higher in week 1 (79.5% ) than in subsequent weeks (week 2, 70.3%; week 3, 67.4%; week 4, 73.0%; P = .041). In the 17.8% of women who underwent mammography for the first time in this study, sensitivity tended to be lower during the follicular phase (week 1, 72.1%; week 2, 80.4%; week 3, 84.6%; week 4, 93.8%; P =.051). Sensitivity did not vary significantly by week in menstrual cycle in women who had undergone mammography more than 3 years earlier. There were no clinically meaningful differences in specificity or cancer detection rate. Conclusion: Premenopausal women who undergo regular screening may benefit from higher sensitivity of mammography if they schedule screening mammography during the 1st week of their menstrual cycle.

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