Accuracy of real-time three-dimensional echocardiography for quantifying right ventricular volume: Static and pulsatile flow studies in an anatomic in vitro model

Sebastian T. Schindera, Petra S. Mehwald, David Sahn, Deniz Kececioglu

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Objective. The complex structural geometry of the right ventricle hinders accurate assessment of right ventricular volume and function on conventional two-dimensional echocardiography. We sought to evaluate the accuracy of real-time three-dimensional echocardiography for quantifying the volume of the right ventricle in an in vitro experimental study. Methods. We developed 39 anatomically accurate latex phantoms of human and porcine right ventricles (range, 24-108 mL) for 39 static and 10 pulsatile models. Real-time three-dimensional scanning was performed with the models placed in a water bath and with a 3.5-MHz probe. In the dynamic models a pulsatile flow pump generated 2 different stroke volumes (29 and 64 mL/beat). Static chamber volumes and stroke volumes were verified by water displacement, which served as a reference standard. Three-dimensional echo right ventricle volumes were determined by tracing derived B- and C-scans, using the Simpson rule. Results. Multiple regression analyses showed an excellent correlation between real-time three-dimensional echocardiographic determinations and the static volumes (B-scan, r = 0.99; C-scan, r = 0.98; P <.001), as well as stroke volumes in the dynamic model (B-scan, r = 0.90; C-scan, r = 0.86; P <.001). However, the C-scans tended to underestimate cavity and stroke volumes more than the B-scans (mean difference for static volume: B-scan, 1.4% ± 9.8%; C-scan, -7.4% ± 8.0%; P <.001; mean difference for stroke volumes: B-scan, 3.0% ± 19.1%; C-scan, -2.5% ± 20.9%; P <.001). Conclusions. Real-time three-dimensional echocardiography can accurately quantify right ventricle cavity volumes and stroke volumes without geometric assumptions.

Original languageEnglish (US)
Pages (from-to)1069-1075
Number of pages7
JournalJournal of Ultrasound in Medicine
Volume21
Issue number10
StatePublished - Oct 1 2002
Externally publishedYes

Fingerprint

Three-Dimensional Echocardiography
echocardiography
Pulsatile Flow
Stroke Volume
stroke volume
Heart Ventricles
Right Ventricular Function
Water
dynamic models
Latex
Baths
Echocardiography
In Vitro Techniques
Swine
Regression Analysis
cavities
tracing
latex
water
regression analysis

Keywords

  • Congenital heart disease
  • Right ventricle
  • Three-dimensional sonography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Acoustics and Ultrasonics

Cite this

Accuracy of real-time three-dimensional echocardiography for quantifying right ventricular volume : Static and pulsatile flow studies in an anatomic in vitro model. / Schindera, Sebastian T.; Mehwald, Petra S.; Sahn, David; Kececioglu, Deniz.

In: Journal of Ultrasound in Medicine, Vol. 21, No. 10, 01.10.2002, p. 1069-1075.

Research output: Contribution to journalArticle

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title = "Accuracy of real-time three-dimensional echocardiography for quantifying right ventricular volume: Static and pulsatile flow studies in an anatomic in vitro model",
abstract = "Objective. The complex structural geometry of the right ventricle hinders accurate assessment of right ventricular volume and function on conventional two-dimensional echocardiography. We sought to evaluate the accuracy of real-time three-dimensional echocardiography for quantifying the volume of the right ventricle in an in vitro experimental study. Methods. We developed 39 anatomically accurate latex phantoms of human and porcine right ventricles (range, 24-108 mL) for 39 static and 10 pulsatile models. Real-time three-dimensional scanning was performed with the models placed in a water bath and with a 3.5-MHz probe. In the dynamic models a pulsatile flow pump generated 2 different stroke volumes (29 and 64 mL/beat). Static chamber volumes and stroke volumes were verified by water displacement, which served as a reference standard. Three-dimensional echo right ventricle volumes were determined by tracing derived B- and C-scans, using the Simpson rule. Results. Multiple regression analyses showed an excellent correlation between real-time three-dimensional echocardiographic determinations and the static volumes (B-scan, r = 0.99; C-scan, r = 0.98; P <.001), as well as stroke volumes in the dynamic model (B-scan, r = 0.90; C-scan, r = 0.86; P <.001). However, the C-scans tended to underestimate cavity and stroke volumes more than the B-scans (mean difference for static volume: B-scan, 1.4{\%} ± 9.8{\%}; C-scan, -7.4{\%} ± 8.0{\%}; P <.001; mean difference for stroke volumes: B-scan, 3.0{\%} ± 19.1{\%}; C-scan, -2.5{\%} ± 20.9{\%}; P <.001). Conclusions. Real-time three-dimensional echocardiography can accurately quantify right ventricle cavity volumes and stroke volumes without geometric assumptions.",
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AU - Sahn, David

AU - Kececioglu, Deniz

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N2 - Objective. The complex structural geometry of the right ventricle hinders accurate assessment of right ventricular volume and function on conventional two-dimensional echocardiography. We sought to evaluate the accuracy of real-time three-dimensional echocardiography for quantifying the volume of the right ventricle in an in vitro experimental study. Methods. We developed 39 anatomically accurate latex phantoms of human and porcine right ventricles (range, 24-108 mL) for 39 static and 10 pulsatile models. Real-time three-dimensional scanning was performed with the models placed in a water bath and with a 3.5-MHz probe. In the dynamic models a pulsatile flow pump generated 2 different stroke volumes (29 and 64 mL/beat). Static chamber volumes and stroke volumes were verified by water displacement, which served as a reference standard. Three-dimensional echo right ventricle volumes were determined by tracing derived B- and C-scans, using the Simpson rule. Results. Multiple regression analyses showed an excellent correlation between real-time three-dimensional echocardiographic determinations and the static volumes (B-scan, r = 0.99; C-scan, r = 0.98; P <.001), as well as stroke volumes in the dynamic model (B-scan, r = 0.90; C-scan, r = 0.86; P <.001). However, the C-scans tended to underestimate cavity and stroke volumes more than the B-scans (mean difference for static volume: B-scan, 1.4% ± 9.8%; C-scan, -7.4% ± 8.0%; P <.001; mean difference for stroke volumes: B-scan, 3.0% ± 19.1%; C-scan, -2.5% ± 20.9%; P <.001). Conclusions. Real-time three-dimensional echocardiography can accurately quantify right ventricle cavity volumes and stroke volumes without geometric assumptions.

AB - Objective. The complex structural geometry of the right ventricle hinders accurate assessment of right ventricular volume and function on conventional two-dimensional echocardiography. We sought to evaluate the accuracy of real-time three-dimensional echocardiography for quantifying the volume of the right ventricle in an in vitro experimental study. Methods. We developed 39 anatomically accurate latex phantoms of human and porcine right ventricles (range, 24-108 mL) for 39 static and 10 pulsatile models. Real-time three-dimensional scanning was performed with the models placed in a water bath and with a 3.5-MHz probe. In the dynamic models a pulsatile flow pump generated 2 different stroke volumes (29 and 64 mL/beat). Static chamber volumes and stroke volumes were verified by water displacement, which served as a reference standard. Three-dimensional echo right ventricle volumes were determined by tracing derived B- and C-scans, using the Simpson rule. Results. Multiple regression analyses showed an excellent correlation between real-time three-dimensional echocardiographic determinations and the static volumes (B-scan, r = 0.99; C-scan, r = 0.98; P <.001), as well as stroke volumes in the dynamic model (B-scan, r = 0.90; C-scan, r = 0.86; P <.001). However, the C-scans tended to underestimate cavity and stroke volumes more than the B-scans (mean difference for static volume: B-scan, 1.4% ± 9.8%; C-scan, -7.4% ± 8.0%; P <.001; mean difference for stroke volumes: B-scan, 3.0% ± 19.1%; C-scan, -2.5% ± 20.9%; P <.001). Conclusions. Real-time three-dimensional echocardiography can accurately quantify right ventricle cavity volumes and stroke volumes without geometric assumptions.

KW - Congenital heart disease

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KW - Three-dimensional sonography

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