Accuracy of Knowledge-Based Reconstruction for Measurement of Right Ventricular Volume and Function in Patients With Tetralogy of Fallot

Florence H. Sheehan, Philip J. Kilner, David J. Sahn, G. Wesley Vick, Karen K. Stout, Shuping Ge, Willem A. Helbing, Mark Lewin, Alan J. Shurman, Emanuela Valsangiacomo Buechel, Harold I. Litt, Mary Pierre Waiss

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

We tested the accuracy and reproducibility of knowledge-based reconstruction (KBR) for measuring right ventricular (RV) volume and function. KBR enables rapid assessment of the right ventricle from sparse user input by referencing a database. KBR generates a 3-dimensional surface to fit points that the user enters at anatomic landmarks. We measured the RV volume using KBR from magnetic resonance images in 20 patients with repaired tetralogy of Fallot at end-diastole and end-systole. We entered points in the long- and short-axis and/or oblique views. The true volume was computed by manually tracing the RV borders for 3-dimensional reconstruction using the piecewise smooth subdivision surface method. The reference database included 54 patients with tetralogy of Fallot patients. The KBR values agreed closely with the true values for the end-diastolic volume (r = 0.993), end-systolic volume (r = 0.992), and ejection fraction (EF; r = 0.930). KBR slightly overestimated the end-diastolic volume (4 ± 10 ml, p = NS), end-systolic volume (1 ± 9 ml, p = NS), and EF (4 ± 3%, p = NS). No bias in the error was found by Bland-Altman analysis (p = NS for end-diastolic and end-systolic volume and EF). The KBR volumes had approached the true volumes (235 ± 93 vs 243 ± 93, p = 0.012, r = 0.978 for end-diastolic and end-systolic volumes combined) already after the first run and the entry of 19 ± 3 points. In conclusion, KBR provided accurate measurement of the RV volume and EF with minimal user input. KBR is a clinically feasible alternative to full manual tracing of the heart borders from imaging data.

Original languageEnglish (US)
Pages (from-to)993-999
Number of pages7
JournalAmerican Journal of Cardiology
Volume105
Issue number7
DOIs
StatePublished - Apr 1 2010

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Sheehan, F. H., Kilner, P. J., Sahn, D. J., Vick, G. W., Stout, K. K., Ge, S., Helbing, W. A., Lewin, M., Shurman, A. J., Buechel, E. V., Litt, H. I., & Waiss, M. P. (2010). Accuracy of Knowledge-Based Reconstruction for Measurement of Right Ventricular Volume and Function in Patients With Tetralogy of Fallot. American Journal of Cardiology, 105(7), 993-999. https://doi.org/10.1016/j.amjcard.2009.11.032