Accumulation of fluoxetine and norfluoxetine in human brain during therapeutic administration

P. F. Renshaw, A. R. Guimaraes, M. Fava, J. F. Rosenbaum, J. D. Pearlman, J. G. Flood, P. R. Puopolo, K. Clancy, R. G. Gonzalez

Research output: Contribution to journalArticle

81 Scopus citations

Abstract

In vivo 19fluorine nuclear magnetic resonance spectroscopy was used to measure the brain concentration of fluoxetine and norfluoxetine in five patients with obsessive-compulsive disorder and three with major depression. The mean brain:plasma ratio of the parent drug plus the metabolite was significantly elevated to 2.6 (SD=1.0) (95% confidence interval=1.9-3.3). This accumulation may have implications for understanding both the therapeutic and the toxic effects of fluoxetine.

Original languageEnglish (US)
Pages (from-to)1592-1594
Number of pages3
JournalAmerican Journal of Psychiatry
Volume149
Issue number11
DOIs
StatePublished - 1992

ASJC Scopus subject areas

  • Psychiatry and Mental health

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    Renshaw, P. F., Guimaraes, A. R., Fava, M., Rosenbaum, J. F., Pearlman, J. D., Flood, J. G., Puopolo, P. R., Clancy, K., & Gonzalez, R. G. (1992). Accumulation of fluoxetine and norfluoxetine in human brain during therapeutic administration. American Journal of Psychiatry, 149(11), 1592-1594. https://doi.org/10.1176/ajp.149.11.1592