Accretion of n-3 fatty acids in the brain and retina of chicks fed a low- linolenic acid diet supplemented with docosahexaenoic acid

G. J. Anderson, W. E. Connor

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Diets low in α-linolenic acid may not support normal brain accretion of n-3 fatty acids. An n-3 fatty acid-deficient diet was fed to laying hens and the resulting deficient chicks were fed a low-linolenic acid diet based on corn oil, or the same diet supplemented with docosahexaenoic acid. Control chicks from soybean oil-fed hens were fed a soybean oil-based diet. The fatty acid composition of the chick brains, retinas, livers, and serum was determined after 0-4 wk. The corn oil diet did not reverse the deficiency but the combination of corn oil and docosahexaenoic acid rapidly restored brain and retinal concentrations of docosahexaenoic acid. Supplemented chicks, however, showed a slight lowering of arachidonic acid in the brain and serum. This study demonstrates that a low-linolenic acid diet without docosahexaenoic acid fails to support accretion of n-3 fatty acids in the nervous tissue of chicks.

Original languageEnglish (US)
Pages (from-to)1338-1346
Number of pages9
JournalAmerican Journal of Clinical Nutrition
Volume59
Issue number6
DOIs
StatePublished - Jan 1 1994

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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