TY - JOUR
T1 - Accessories to the Crime
T2 - Functions of Cells Recruited to the Tumor Microenvironment
AU - Hanahan, Douglas
AU - Coussens, Lisa M.
PY - 2012/3/20
Y1 - 2012/3/20
N2 - Mutationally corrupted cancer (stem) cells are the driving force of tumor development and progression. Yet, these transformed cells cannot do it alone. Assemblages of ostensibly normal tissue and bone marrow-derived (stromal) cells are recruited to constitute tumorigenic microenvironments. Most of the hallmarks of cancer are enabled and sustained to varying degrees through contributions from repertoires of stromal cell types and distinctive subcell types. Their contributory functions to hallmark capabilities are increasingly well understood, as are the reciprocal communications with neoplastic cancer cells that mediate their recruitment, activation, programming, and persistence. This enhanced understanding presents interesting new targets for anticancer therapy.
AB - Mutationally corrupted cancer (stem) cells are the driving force of tumor development and progression. Yet, these transformed cells cannot do it alone. Assemblages of ostensibly normal tissue and bone marrow-derived (stromal) cells are recruited to constitute tumorigenic microenvironments. Most of the hallmarks of cancer are enabled and sustained to varying degrees through contributions from repertoires of stromal cell types and distinctive subcell types. Their contributory functions to hallmark capabilities are increasingly well understood, as are the reciprocal communications with neoplastic cancer cells that mediate their recruitment, activation, programming, and persistence. This enhanced understanding presents interesting new targets for anticancer therapy.
UR - http://www.scopus.com/inward/record.url?scp=84858590826&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84858590826&partnerID=8YFLogxK
U2 - 10.1016/j.ccr.2012.02.022
DO - 10.1016/j.ccr.2012.02.022
M3 - Review article
C2 - 22439926
AN - SCOPUS:84858590826
SN - 1535-6108
VL - 21
SP - 309
EP - 322
JO - Cancer Cell
JF - Cancer Cell
IS - 3
ER -