Accelerating the drug delivery pipeline for acute and chronic pancreatitis: Summary of the working group on drug development and trials in chronic pancreatitis at the National Institute of Diabetes and Digestive and Kidney Diseases workshop

Christopher E. Forsmark; Dana K. Andersen; John T. Farrar; Megan Golden; Aida Habtezion; Sohail Z. Husain; Liang Li; Julia Mayerle; Stephen J. Pandol; Aliye Uc; Zixi Zhu; Dhiraj Yadav

doi:10.1097/MPA.0000000000001174

Accelerating the drug delivery pipeline for acute and chronic pancreatitis: Summary of the working group on drug development and trials in chronic pancreatitis at the National Institute of Diabetes and Digestive and Kidney Diseases workshop

Christopher E. Forsmark, Dana K. Andersen, John T. Farrar, Megan Golden, Aida Habtezion, Sohail Z. Husain, Liang Li, Julia Mayerle, Stephen J. Pandol, Aliye Uc, Zixi Zhu, Dhiraj Yadav

Gastroenterology and Hepatology

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

The lack of effective therapeutic agents specifically tailored for chronic pancreatitis (CP) has hampered clinical care and negatively impacted patients' lives. New mechanistic insights now point to novel therapies, which involve both recently developed and/or repurposed agents. This working group focused on 2 main outcomes for CP: Pain and progression of disease. The goal is to frame the essential aspects of trial design including patient-centered outcomes, proposed methods to measure the outcomes of pain and progression, and study design considerations for future trials to facilitate rapid drug development for patients with CP.

Original language	English (US)
Pages (from-to)	1200-1207
Number of pages	8
Journal	Pancreas
Volume	47
Issue number	10
DOIs	https://doi.org/10.1097/MPA.0000000000001174
State	Published - Nov 1 2018

Keywords

chronic pancreatitis
clinical trial design
natural history of chronic pancreatitis
pain in chronic pancreatitis

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism
Hepatology
Endocrinology

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Forsmark, C. E., Andersen, D. K., Farrar, J. T., Golden, M., Habtezion, A., Husain, S. Z., Li, L., Mayerle, J., Pandol, S. J., Uc, A., Zhu, Z., & Yadav, D. (2018). Accelerating the drug delivery pipeline for acute and chronic pancreatitis: Summary of the working group on drug development and trials in chronic pancreatitis at the National Institute of Diabetes and Digestive and Kidney Diseases workshop. Pancreas, 47(10), 1200-1207. https://doi.org/10.1097/MPA.0000000000001174

Accelerating the drug delivery pipeline for acute and chronic pancreatitis: Summary of the working group on drug development and trials in chronic pancreatitis at the National Institute of Diabetes and Digestive and Kidney Diseases workshop. / Forsmark, Christopher E.; Andersen, Dana K.; Farrar, John T. et al.
In: Pancreas, Vol. 47, No. 10, 01.11.2018, p. 1200-1207.

Research output: Contribution to journal › Article › peer-review

Forsmark, CE, Andersen, DK, Farrar, JT, Golden, M, Habtezion, A, Husain, SZ, Li, L, Mayerle, J, Pandol, SJ, Uc, A, Zhu, Z & Yadav, D 2018, 'Accelerating the drug delivery pipeline for acute and chronic pancreatitis: Summary of the working group on drug development and trials in chronic pancreatitis at the National Institute of Diabetes and Digestive and Kidney Diseases workshop', Pancreas, vol. 47, no. 10, pp. 1200-1207. https://doi.org/10.1097/MPA.0000000000001174

Forsmark CE, Andersen DK, Farrar JT, Golden M, Habtezion A, Husain SZ et al. Accelerating the drug delivery pipeline for acute and chronic pancreatitis: Summary of the working group on drug development and trials in chronic pancreatitis at the National Institute of Diabetes and Digestive and Kidney Diseases workshop. Pancreas. 2018 Nov 1;47(10):1200-1207. doi: 10.1097/MPA.0000000000001174

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abstract = "The lack of effective therapeutic agents specifically tailored for chronic pancreatitis (CP) has hampered clinical care and negatively impacted patients' lives. New mechanistic insights now point to novel therapies, which involve both recently developed and/or repurposed agents. This working group focused on 2 main outcomes for CP: Pain and progression of disease. The goal is to frame the essential aspects of trial design including patient-centered outcomes, proposed methods to measure the outcomes of pain and progression, and study design considerations for future trials to facilitate rapid drug development for patients with CP.",

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Accelerating the drug delivery pipeline for acute and chronic pancreatitis: Summary of the working group on drug development and trials in chronic pancreatitis at the National Institute of Diabetes and Digestive and Kidney Diseases workshop

Abstract

Keywords

ASJC Scopus subject areas

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