Accelerating the drug delivery pipeline for acute and chronic pancreatitis: Summary of the working group on drug development and trials in chronic pancreatitis at the National Institute of Diabetes and Digestive and Kidney Diseases workshop

Christopher E. Forsmark, Dana K. Andersen, John T. Farrar, Megan Golden, Aida Habtezion, Sohail Z. Husain, Liang Li, Julia Mayerle, Stephen J. Pandol, Aliye Uc, Zixi Zhu, Dhiraj Yadav

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

The lack of effective therapeutic agents specifically tailored for chronic pancreatitis (CP) has hampered clinical care and negatively impacted patients' lives. New mechanistic insights now point to novel therapies, which involve both recently developed and/or repurposed agents. This working group focused on 2 main outcomes for CP: Pain and progression of disease. The goal is to frame the essential aspects of trial design including patient-centered outcomes, proposed methods to measure the outcomes of pain and progression, and study design considerations for future trials to facilitate rapid drug development for patients with CP.

Original languageEnglish (US)
Pages (from-to)1200-1207
Number of pages8
JournalPancreas
Volume47
Issue number10
DOIs
StatePublished - Nov 1 2018

Keywords

  • chronic pancreatitis
  • clinical trial design
  • natural history of chronic pancreatitis
  • pain in chronic pancreatitis

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

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