Accelerated immune senescence and reduced response to vaccination in ovariectomized female rhesus macaques

Flora Engelmann, Alex Barron, Henryk Urbanski, Martha Neuringer, Steven Kohama, Byung Park, Ilhem Messaoudi

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Aging is associated with a general dysregulation in immune function, commonly referred to as "immune senescence". Several studies have shown that female sex steroids can modulate the immune response. However, the impact of menopauseassociated loss of estrogen and progestins on immune senescence remains poorly understood. To help answer this question, we examined the effect of ovariectomy on T-cell homeostasis and function in adult and aged female rhesus macaques. Our data show that in adult female rhesus macaques, ovariectomy increased the frequency of naïve CD4 T cells. In contrast, ovariectomized (ovx) aged female rhesus macaques had increased frequency of terminally differentiated CD4 effector memory T cells and inflammatory cytokine-secreting memory T cells. Moreover, ovariectomy reduced the immune response (T-cell cytokine and IgG production) following vaccination with modified vaccinia ankara in both adult and aged female rhesus macaques compared to ovary-intact age-matched controls. Interestingly, hormone therapy (estradiol alone or in conjunction with progesterone) partially improved the T-cell response to vaccination in aged ovariectomized female rhesus macaques. These data suggest that the loss of ovarian steroids, notably estradiol and progesterone, may contribute to reduced immune function in postmenopausal women and that hormone therapy may improve immune response to vaccination in this growing segment of the population.

Original languageEnglish (US)
Pages (from-to)275-289
Number of pages15
JournalAge
Volume33
Issue number3
DOIs
StatePublished - Sep 2011

Fingerprint

Macaca mulatta
Vaccination
T-Lymphocytes
Ovariectomy
Progesterone
Estradiol
Steroids
Hormones
Cytokines
Vaccinia
Progestins
Ovary
Estrogens
Homeostasis
Immunoglobulin G
Therapeutics
Population

Keywords

  • Aging
  • Estrogen
  • Immune senescence
  • Ovariectomy
  • Progestin
  • Tcells
  • Vaccine

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

Cite this

Accelerated immune senescence and reduced response to vaccination in ovariectomized female rhesus macaques. / Engelmann, Flora; Barron, Alex; Urbanski, Henryk; Neuringer, Martha; Kohama, Steven; Park, Byung; Messaoudi, Ilhem.

In: Age, Vol. 33, No. 3, 09.2011, p. 275-289.

Research output: Contribution to journalArticle

Engelmann, Flora ; Barron, Alex ; Urbanski, Henryk ; Neuringer, Martha ; Kohama, Steven ; Park, Byung ; Messaoudi, Ilhem. / Accelerated immune senescence and reduced response to vaccination in ovariectomized female rhesus macaques. In: Age. 2011 ; Vol. 33, No. 3. pp. 275-289.
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