Acanthamoeba keratitis: The persistence of cases following a multistate outbreak

Jonathan S. Yoder, Jennifer Verani, Nancy Heidman, Joan Hoppe-Bauer, Eduardo C. Alfonso, Darlene Miller, Dan B. Jones, David Bruckner, Roger Langston, Bennie H. Jeng, Charlotte E. Joslin, Elmer Tu, Kathryn Colby, Emily Vetter, David Ritterband, William Mathers, Regis P. Kowalski, Nisha R. Acharya, Ajit P. Limaye, Charles LeiterSharon Roy, Suchita Lorick, Jacquelin Roberts, Michael J. Beach

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Purpose: To describe the trend of Acanthamoeba keratitis case reports following an outbreak and the recall of a multipurpose contact lens disinfection solution. Acanthamoeba keratitis is a serious eye infection caused by the free-living amoeba Acanthamoeba that primarily affects contact lens users. Methods: A convenience sample of 13 ophthalmology centers and laboratories in the USA, provided annual numbers of Acanthamoeba keratitis cases diagnosed between 1999-2009 and monthly numbers of cases diagnosed between 2007-2009. Data on ophthalmic preparations of anti-Acanthamoeba therapies were collected from a national compounding pharmacy. Results: Data from sentinel site ophthalmology centers and laboratories revealed that the yearly number of cases gradually increased from 22 in 1999 to 43 in 2003, with a marked increase beginning in 2004 (93 cases) that continued through 2007 (170 cases; p <0.0001). The outbreak identified from these sentinel sites resulted in the recall of a contact lens disinfecting solution. There was a statistically significant (p ≤ 0.0001) decrease in monthly cases reported from 28 cases in June 2007 (following the recall) to seven cases in June 2008, followed by an increase (p = 0.0004) in reported cases thereafter; cases have remained higher than pre-outbreak levels. A similar trend was seen in prescriptions for Acanthamoeba keratitis chemotherapy. Cases were significantly more likely to be reported during summer than during other seasons. Conclusion: The persistently elevated number of reported cases supports the need to understand the risk factors and environmental exposures associated with Acanthamoeba keratitis. Further prevention efforts are needed to reduce the number of cases occurring among contact lens wearers.

Original languageEnglish (US)
Pages (from-to)221-225
Number of pages5
JournalOphthalmic Epidemiology
Volume19
Issue number4
DOIs
StatePublished - Aug 2012

Fingerprint

Acanthamoeba Keratitis
Disease Outbreaks
Contact Lens Solutions
Acanthamoeba
Contact Lenses
Ophthalmology
Eye Infections
Amoeba
Disinfection
Environmental Exposure
Prescriptions
Drug Therapy

Keywords

  • Acanthamoeba keratitis
  • Contacts lens
  • Epidemiology
  • Outbreak
  • Surveillance

ASJC Scopus subject areas

  • Ophthalmology
  • Epidemiology

Cite this

Yoder, J. S., Verani, J., Heidman, N., Hoppe-Bauer, J., Alfonso, E. C., Miller, D., ... Beach, M. J. (2012). Acanthamoeba keratitis: The persistence of cases following a multistate outbreak. Ophthalmic Epidemiology, 19(4), 221-225. https://doi.org/10.3109/09286586.2012.681336

Acanthamoeba keratitis : The persistence of cases following a multistate outbreak. / Yoder, Jonathan S.; Verani, Jennifer; Heidman, Nancy; Hoppe-Bauer, Joan; Alfonso, Eduardo C.; Miller, Darlene; Jones, Dan B.; Bruckner, David; Langston, Roger; Jeng, Bennie H.; Joslin, Charlotte E.; Tu, Elmer; Colby, Kathryn; Vetter, Emily; Ritterband, David; Mathers, William; Kowalski, Regis P.; Acharya, Nisha R.; Limaye, Ajit P.; Leiter, Charles; Roy, Sharon; Lorick, Suchita; Roberts, Jacquelin; Beach, Michael J.

In: Ophthalmic Epidemiology, Vol. 19, No. 4, 08.2012, p. 221-225.

Research output: Contribution to journalArticle

Yoder, JS, Verani, J, Heidman, N, Hoppe-Bauer, J, Alfonso, EC, Miller, D, Jones, DB, Bruckner, D, Langston, R, Jeng, BH, Joslin, CE, Tu, E, Colby, K, Vetter, E, Ritterband, D, Mathers, W, Kowalski, RP, Acharya, NR, Limaye, AP, Leiter, C, Roy, S, Lorick, S, Roberts, J & Beach, MJ 2012, 'Acanthamoeba keratitis: The persistence of cases following a multistate outbreak', Ophthalmic Epidemiology, vol. 19, no. 4, pp. 221-225. https://doi.org/10.3109/09286586.2012.681336
Yoder JS, Verani J, Heidman N, Hoppe-Bauer J, Alfonso EC, Miller D et al. Acanthamoeba keratitis: The persistence of cases following a multistate outbreak. Ophthalmic Epidemiology. 2012 Aug;19(4):221-225. https://doi.org/10.3109/09286586.2012.681336
Yoder, Jonathan S. ; Verani, Jennifer ; Heidman, Nancy ; Hoppe-Bauer, Joan ; Alfonso, Eduardo C. ; Miller, Darlene ; Jones, Dan B. ; Bruckner, David ; Langston, Roger ; Jeng, Bennie H. ; Joslin, Charlotte E. ; Tu, Elmer ; Colby, Kathryn ; Vetter, Emily ; Ritterband, David ; Mathers, William ; Kowalski, Regis P. ; Acharya, Nisha R. ; Limaye, Ajit P. ; Leiter, Charles ; Roy, Sharon ; Lorick, Suchita ; Roberts, Jacquelin ; Beach, Michael J. / Acanthamoeba keratitis : The persistence of cases following a multistate outbreak. In: Ophthalmic Epidemiology. 2012 ; Vol. 19, No. 4. pp. 221-225.
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