Absolute measurement of subnanometer scale vibration of cochlear partition of an excised guinea pig cochlea using spectral-domain phase-sensitive optical coherence tomography

Hrebesh M. Subhash, Niloy Choudhury, Steven L. Jacques, Ruikang K. Wang, Fangyi Chen, Dingjun Zha, Alfred L. Nuttall

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Direct measurement of absolute vibration parameters from different locations within the mammalian organ of Corti is crucial for understanding the hearing mechanics such as how sound propagates through the cochlea and how sound stimulates the vibration of various structures of the cochlea, namely, basilar membrane (BM), recticular lamina, outer hair cells and tectorial membrane (TM). In this study we demonstrate the feasibility a modified phase-sensitive spectral domain optical coherence tomography system to provide subnanometer scale vibration information from multiple angles within the imaging beam. The system has the potential to provide depth resolved absolute vibration measurement of tissue microstructures from each of the delay-encoded vibration images with a noise floor of ∼0.3nm at 200Hz.

Original languageEnglish (US)
Title of host publicationOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI
PublisherSPIE
ISBN (Print)9780819488565
DOIs
StatePublished - Jan 1 2012
EventOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI - San Francisco, CA, United States
Duration: Jan 23 2012Jan 25 2012

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8213
ISSN (Print)1605-7422

Other

OtherOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI
CountryUnited States
CitySan Francisco, CA
Period1/23/121/25/12

Keywords

  • Biomedical optical imaging
  • Hearing research
  • Image processing
  • Optical interferometry
  • Optical vibrometry
  • Phase-sensitive Optical coherence tomography
  • Spectral interferometry

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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    Subhash, H. M., Choudhury, N., Jacques, S. L., Wang, R. K., Chen, F., Zha, D., & Nuttall, A. L. (2012). Absolute measurement of subnanometer scale vibration of cochlear partition of an excised guinea pig cochlea using spectral-domain phase-sensitive optical coherence tomography. In Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI [82131V] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 8213). SPIE. https://doi.org/10.1117/12.907900