Absolute measurement of subnanometer scale vibration of cochlear partition of an excised guinea pig cochlea using spectral-domain phase-sensitive optical coherence tomography

Hrebesh M. Subhash, Niloy Choudhury, Steven Jacques, Ruikang K. Wang, Fangyi Chen, Dingjun Zha, Alfred Nuttall

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Direct measurement of absolute vibration parameters from different locations within the mammalian organ of Corti is crucial for understanding the hearing mechanics such as how sound propagates through the cochlea and how sound stimulates the vibration of various structures of the cochlea, namely, basilar membrane (BM), recticular lamina, outer hair cells and tectorial membrane (TM). In this study we demonstrate the feasibility a modified phase-sensitive spectral domain optical coherence tomography system to provide subnanometer scale vibration information from multiple angles within the imaging beam. The system has the potential to provide depth resolved absolute vibration measurement of tissue microstructures from each of the delay-encoded vibration images with a noise floor of ∼0.3nm at 200Hz.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
PublisherSPIE
Volume8213
ISBN (Print)9780819488565
DOIs
StatePublished - 2012
EventOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI - San Francisco, CA, United States
Duration: Jan 23 2012Jan 25 2012

Other

OtherOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI
CountryUnited States
CitySan Francisco, CA
Period1/23/121/25/12

Fingerprint

guinea pigs
cochlea
Optical tomography
Cochlea
Optical Coherence Tomography
Vibration
partitions
Guinea Pigs
tomography
Acoustic waves
Membranes
vibration
Vibration measurement
Audition
Vibrations (mechanical)
Mechanics
Outer Auditory Hair Cells
Cells
Tissue
membranes

Keywords

  • Biomedical optical imaging
  • Hearing research
  • Image processing
  • Optical interferometry
  • Optical vibrometry
  • Phase-sensitive Optical coherence tomography
  • Spectral interferometry

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Subhash, H. M., Choudhury, N., Jacques, S., Wang, R. K., Chen, F., Zha, D., & Nuttall, A. (2012). Absolute measurement of subnanometer scale vibration of cochlear partition of an excised guinea pig cochlea using spectral-domain phase-sensitive optical coherence tomography. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 8213). [82131V] SPIE. https://doi.org/10.1117/12.907900

Absolute measurement of subnanometer scale vibration of cochlear partition of an excised guinea pig cochlea using spectral-domain phase-sensitive optical coherence tomography. / Subhash, Hrebesh M.; Choudhury, Niloy; Jacques, Steven; Wang, Ruikang K.; Chen, Fangyi; Zha, Dingjun; Nuttall, Alfred.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8213 SPIE, 2012. 82131V.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Subhash, HM, Choudhury, N, Jacques, S, Wang, RK, Chen, F, Zha, D & Nuttall, A 2012, Absolute measurement of subnanometer scale vibration of cochlear partition of an excised guinea pig cochlea using spectral-domain phase-sensitive optical coherence tomography. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 8213, 82131V, SPIE, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI, San Francisco, CA, United States, 1/23/12. https://doi.org/10.1117/12.907900
Subhash HM, Choudhury N, Jacques S, Wang RK, Chen F, Zha D et al. Absolute measurement of subnanometer scale vibration of cochlear partition of an excised guinea pig cochlea using spectral-domain phase-sensitive optical coherence tomography. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8213. SPIE. 2012. 82131V https://doi.org/10.1117/12.907900
Subhash, Hrebesh M. ; Choudhury, Niloy ; Jacques, Steven ; Wang, Ruikang K. ; Chen, Fangyi ; Zha, Dingjun ; Nuttall, Alfred. / Absolute measurement of subnanometer scale vibration of cochlear partition of an excised guinea pig cochlea using spectral-domain phase-sensitive optical coherence tomography. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8213 SPIE, 2012.
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