Absence of Detectable IgM Antibody during Cytomegalovirus Disease in Patients with AIDS

Joseph Dylewski, Sunwen Chou, Thomas C. Merigan

Research output: Contribution to journalLetter

38 Scopus citations

Abstract

To the Editor: A great deal of emphasis has been placed on the cell-mediated immune deficits seen in patients with the acquired immunodeficiency syndrome (AIDS).1 2 3 Reports of normal or elevated levels of circulating immunoglobulins have suggested that the humoral system is intact.2,3 Indeed, high levels of IgG-class antibody to cytomegalovirus, Epstein–Barr virus, and hepatitis B are commonly seen in homosexual men with AIDS. Luft et al.4 have described 10 patients with pathologically documented Central-nervous-system toxoplasmosis, with demonstrable IgG but no IgM antibodies to toxoplasma. According to the Centers for Disease Control criteria, these patients would be classified as having AIDS.

Original languageEnglish (US)
Number of pages1
JournalNew England Journal of Medicine
Volume309
Issue number8
DOIs
StatePublished - Aug 25 1983

ASJC Scopus subject areas

  • Medicine(all)

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