Absence of clonal beta and gamma T-cell receptor gene rearrangements in a subset of peripheral T-cell lymphomas

L. M. Weiss, Louis Picker, T. M. Grogan, R. A. Warnke, J. Sklar

Research output: Contribution to journalArticle

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Abstract

The authors describe a set of seven peripheral T-cell lymphomas that lack detectable rearrangements of T-cell receptor (TCR) genes. All cases showed antigenic profiles consistent with T-cell lymphoma, including expression of Leu-5 (CD2) antigen. However, few other T-lineage markers were found, and none of the cases tested (6 of 7) bound antibody recognizing the constant region of the beta TCR protein. Each case showed exclusively germline configurations of DNA for the beta TCR genes in Southern blot analyses with the use of several different combinations of restriction enzymes and DNA hybridization probes. One case contained clonal rearrangements of the gamma TCR gene and of the immunoglobulin heavy chain gene. Our results suggest that certain cases of peripheral T-cell lymphoma may lack rearrangements of TCR genes - particularly those cases expressing restricted numbers of T-lineage antigens. In view of these findings, failure to detect rearrangements of TCR genes by Southern blot analyses is not necessarily inconsistent with malignant lymphocytic proliferations in T-lineage neoplasia.

Original languageEnglish (US)
Pages (from-to)436-442
Number of pages7
JournalAmerican Journal of Pathology
Volume130
Issue number3
StatePublished - 1988
Externally publishedYes

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T-Lymphocyte Gene Rearrangement
Peripheral T-Cell Lymphoma
T-Cell Receptor Genes
T-Cell Antigen Receptor
Southern Blotting
CD2 Antigens
T-Cell Receptor gamma Genes
T-Cell Receptor beta Genes
Immunoglobulin Heavy Chain Genes
T-Cell Lymphoma
Viral Tumor Antigens
DNA Probes
Antibodies
DNA
Enzymes
Neoplasms
Proteins

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Absence of clonal beta and gamma T-cell receptor gene rearrangements in a subset of peripheral T-cell lymphomas. / Weiss, L. M.; Picker, Louis; Grogan, T. M.; Warnke, R. A.; Sklar, J.

In: American Journal of Pathology, Vol. 130, No. 3, 1988, p. 436-442.

Research output: Contribution to journalArticle

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