Abnormal ventilatory response to exercise in adults with congenital heart disease relates to cyanosis and predicts survival

Konstantinos Dimopoulos, Darlington O. Okonko, Gerhard Paul Diller, Craig S. Broberg, Tushar V. Salukhe, Sonya V. Babu-Narayan, Wei Li, Anselm Uebing, Stephanie Bayne, Roland Wensel, Massimo F. Piepoli, Philip A. Poole-Wilson, Darrel P. Francis, Michael A. Gatzoulis

    Research output: Contribution to journalArticle

    188 Scopus citations

    Abstract

    BACKGROUND - Limited data exist with which to stratify risk in adult congenital heart disease (ACHD). An increased ventilatory response to exercise, expressed as ventilation per unit of carbon dioxide production (V̇e/V̇co2 slope), is an established predictor of impaired survival in acquired heart disease. We sought to establish the distribution, relation to cyanosis, and prognostic value of the V̇e/V̇co2 slope across a wide spectrum of ACHD patients. METHODS AND RESULTS - Five hundred sixty ACHD patients of varying diagnoses and 50 healthy controls underwent cardiopulmonary exercise testing at a single laboratory between 2001 and 2004. Patient age was 33.2±12.9 years (mean±SD). Peak oxygen consumption was 23.5±9.0 mL·kg·min. V̇e/V̇co2 slope for all patients was 36.3±15.3. The slope was raised in all ACHD groups compared with controls and was 73% higher in cyanotic patients. Cyanosis, with or without pulmonary arterial hypertension, was the strongest predictor of abnormal V̇e/V̇co2 slope. The V̇e/V̇co2 slope was the most powerful univariate predictor of mortality in the noncyanotic group and the only independent predictor of mortality among exercise parameters on multivariate analysis. In cyanotic patients, no parameter was predictive of death. CONCLUSIONS - Ventilatory response to exercise is abnormal across the spectrum of ACHD. Cyanosis is a powerful stimulus for such exaggerated ventilatory patterns irrespective of the presence of pulmonary arterial hypertension. Increased V̇e/V̇co2 slope is the strongest exercise predictor of death in noncyanotic ACHD patients.

    Original languageEnglish (US)
    Pages (from-to)2796-2802
    Number of pages7
    JournalCirculation
    Volume113
    Issue number24
    DOIs
    StatePublished - Jun 1 2006

    Keywords

    • Congenital heart defects
    • Exercise test
    • Prognosis
    • Ventilation

    ASJC Scopus subject areas

    • Cardiology and Cardiovascular Medicine
    • Physiology (medical)

    Fingerprint Dive into the research topics of 'Abnormal ventilatory response to exercise in adults with congenital heart disease relates to cyanosis and predicts survival'. Together they form a unique fingerprint.

  • Cite this

    Dimopoulos, K., Okonko, D. O., Diller, G. P., Broberg, C. S., Salukhe, T. V., Babu-Narayan, S. V., Li, W., Uebing, A., Bayne, S., Wensel, R., Piepoli, M. F., Poole-Wilson, P. A., Francis, D. P., & Gatzoulis, M. A. (2006). Abnormal ventilatory response to exercise in adults with congenital heart disease relates to cyanosis and predicts survival. Circulation, 113(24), 2796-2802. https://doi.org/10.1161/CIRCULATIONAHA.105.594218