Abnormal scleral findings in uveal effusion syndrome

Robert C. Ward, Evangelos S. Gragoudas, David M. Pon, Daniel M. Albert

Research output: Contribution to journalArticlepeer-review

47 Scopus citations


We successfully treated a patient with uveal effusion syndrome and abnormal sclera with a partial-thickness sclerectomy. Part of the sclera was immediately cultured, and the excised sclera and the cultured cells were examined by electron microscopy. The sclera demonstrated increased glycosaminoglycan-like deposits between the scleral fibers. The cultured scleral cells showed large intracellular glycogen-like deposits, which were not seen in cells cultured from two control scleras. These findings may be the result of a metabolic defect, which causes a thick, impermeable sclera in some cases of uveal effusion.

Original languageEnglish (US)
Pages (from-to)139-146
Number of pages8
JournalAmerican journal of ophthalmology
Issue number2
StatePublished - Aug 15 1988
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology


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