Abnormal myocardial blood flow in children with mild/moderate aortic stenosis

Erin Madriago, Ronald Wells, David Sahn, Brian S. Diggs, Stephen M. Langley, Daniel J. Woodward, Michael Jerosch-Herold, Gary (Michael) Silberbach

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective To quantify myocardial blood flow in infants and children with mild or moderate aortic stenosis using adenosine-infusion cardiac magnetic resonance. Background It is unclear whether asymptomatic children with mild/moderate aortic stenosis have myocardial abnormalities. In addition, cardiac magnetic resonance-determined normative myocardial blood flow data in children have not been reported. Methods We studied 31 infants and children with either haemodynamically normal hearts (n=20, controls) or mild/moderate aortic stenosis (n=11). The left ventricular myocardium was divided into six segments, and the change in average segmental signal intensity during contrast transit was used to quantify absolute flow (ml/g/minute) at rest and during adenosine infusion by deconvolution of the tissue curves with the arterial input of contrast. Results In all the cases, adenosine was well tolerated without complications. The mean pressure gradient between the left ventricle and the ascending aorta was higher in the aortic stenosis group compared with controls (24 versus 3 mmHg, p2, p

Original languageEnglish (US)
Pages (from-to)1358-1366
Number of pages9
JournalCardiology in the Young
Volume25
Issue number7
DOIs
StatePublished - Oct 2 2014

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Aortic Valve Stenosis
Adenosine
Magnetic Resonance Spectroscopy
Heart Ventricles
Aorta
Myocardium
Pressure

Keywords

  • aortic stenosis
  • Congenital heart disease
  • contrast media
  • fibrosis
  • perfusion

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pediatrics, Perinatology, and Child Health

Cite this

Abnormal myocardial blood flow in children with mild/moderate aortic stenosis. / Madriago, Erin; Wells, Ronald; Sahn, David; Diggs, Brian S.; Langley, Stephen M.; Woodward, Daniel J.; Jerosch-Herold, Michael; Silberbach, Gary (Michael).

In: Cardiology in the Young, Vol. 25, No. 7, 02.10.2014, p. 1358-1366.

Research output: Contribution to journalArticle

Madriago, E, Wells, R, Sahn, D, Diggs, BS, Langley, SM, Woodward, DJ, Jerosch-Herold, M & Silberbach, GM 2014, 'Abnormal myocardial blood flow in children with mild/moderate aortic stenosis', Cardiology in the Young, vol. 25, no. 7, pp. 1358-1366. https://doi.org/10.1017/S1047951114002583
Madriago, Erin ; Wells, Ronald ; Sahn, David ; Diggs, Brian S. ; Langley, Stephen M. ; Woodward, Daniel J. ; Jerosch-Herold, Michael ; Silberbach, Gary (Michael). / Abnormal myocardial blood flow in children with mild/moderate aortic stenosis. In: Cardiology in the Young. 2014 ; Vol. 25, No. 7. pp. 1358-1366.
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AU - Woodward, Daniel J.

AU - Jerosch-Herold, Michael

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N2 - Objective To quantify myocardial blood flow in infants and children with mild or moderate aortic stenosis using adenosine-infusion cardiac magnetic resonance. Background It is unclear whether asymptomatic children with mild/moderate aortic stenosis have myocardial abnormalities. In addition, cardiac magnetic resonance-determined normative myocardial blood flow data in children have not been reported. Methods We studied 31 infants and children with either haemodynamically normal hearts (n=20, controls) or mild/moderate aortic stenosis (n=11). The left ventricular myocardium was divided into six segments, and the change in average segmental signal intensity during contrast transit was used to quantify absolute flow (ml/g/minute) at rest and during adenosine infusion by deconvolution of the tissue curves with the arterial input of contrast. Results In all the cases, adenosine was well tolerated without complications. The mean pressure gradient between the left ventricle and the ascending aorta was higher in the aortic stenosis group compared with controls (24 versus 3 mmHg, p2, p

AB - Objective To quantify myocardial blood flow in infants and children with mild or moderate aortic stenosis using adenosine-infusion cardiac magnetic resonance. Background It is unclear whether asymptomatic children with mild/moderate aortic stenosis have myocardial abnormalities. In addition, cardiac magnetic resonance-determined normative myocardial blood flow data in children have not been reported. Methods We studied 31 infants and children with either haemodynamically normal hearts (n=20, controls) or mild/moderate aortic stenosis (n=11). The left ventricular myocardium was divided into six segments, and the change in average segmental signal intensity during contrast transit was used to quantify absolute flow (ml/g/minute) at rest and during adenosine infusion by deconvolution of the tissue curves with the arterial input of contrast. Results In all the cases, adenosine was well tolerated without complications. The mean pressure gradient between the left ventricle and the ascending aorta was higher in the aortic stenosis group compared with controls (24 versus 3 mmHg, p2, p

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