TY - JOUR
T1 - Abnormal fMRI activation pattern during story listening in individuals with Down syndrome
AU - Reynolds Losin, Elizabeth A.
AU - Rivera, Susan M.
AU - O'Hare, Elizabeth D.
AU - Sowell, Elizabeth R.
AU - Pinter, Joseph D.
PY - 2009/9
Y1 - 2009/9
N2 - Down syndrome is characterized by disproportionately severe impairments of speech and language, yet little is known about the neural underpinnings of these deficits. We compared fMRI activation patterns during passive story listening in 9 young adults with Down syndrome and 9 approximately age-matched, typically developing controls. The typically developing group exhibited greater activation than did the Down syndrome group in classical receptive language areas (superior and middle temporal gyri) for forward > backward speech; the Down syndrome group exhibited greater activation in cingulate gyrus, superior and inferior parietal lobules, and precuneus for both forward speech > rest and backward speech > rest. The Down syndrome group showed almost no difference in activation patterns between the language (forward speech) and nonlanguage (backward speech) conditions.
AB - Down syndrome is characterized by disproportionately severe impairments of speech and language, yet little is known about the neural underpinnings of these deficits. We compared fMRI activation patterns during passive story listening in 9 young adults with Down syndrome and 9 approximately age-matched, typically developing controls. The typically developing group exhibited greater activation than did the Down syndrome group in classical receptive language areas (superior and middle temporal gyri) for forward > backward speech; the Down syndrome group exhibited greater activation in cingulate gyrus, superior and inferior parietal lobules, and precuneus for both forward speech > rest and backward speech > rest. The Down syndrome group showed almost no difference in activation patterns between the language (forward speech) and nonlanguage (backward speech) conditions.
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U2 - 10.1352/1944-7558-114.5.369
DO - 10.1352/1944-7558-114.5.369
M3 - Article
C2 - 19928018
AN - SCOPUS:77958467208
SN - 1944-7558
VL - 114
SP - 369
EP - 380
JO - American Journal on Intellectual and Developmental Disabilities
JF - American Journal on Intellectual and Developmental Disabilities
IS - 5
ER -