Abnormal fMRI activation pattern during story listening in individuals with Down syndrome

Elizabeth A. Reynolds Losin, Susan M. Rivera, Elizabeth D. O'Hare, Elizabeth R. Sowell, Joseph Pinter

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Down syndrome is characterized by disproportionately severe impairments of speech and language, yet little is known about the neural underpinnings of these deficits. We compared fMRI activation patterns during passive story listening in 9 young adults with Down syndrome and 9 approximately age-matched, typically developing controls. The typically developing group exhibited greater activation than did the Down syndrome group in classical receptive language areas (superior and middle temporal gyri) for forward > backward speech; the Down syndrome group exhibited greater activation in cingulate gyrus, superior and inferior parietal lobules, and precuneus for both forward speech > rest and backward speech > rest. The Down syndrome group showed almost no difference in activation patterns between the language (forward speech) and nonlanguage (backward speech) conditions.

Original languageEnglish (US)
Pages (from-to)369-380
Number of pages12
JournalAmerican Journal on Intellectual and Developmental Disabilities
Volume114
Issue number5
DOIs
StatePublished - Sep 2009

Fingerprint

Down Syndrome
Magnetic Resonance Imaging
Parietal Lobe
Language
Gyrus Cinguli
Temporal Lobe
Functional Magnetic Resonance Imaging
Activation
Young Adult

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Psychiatry and Mental health
  • Developmental and Educational Psychology
  • Neuropsychology and Physiological Psychology
  • Medicine(all)

Cite this

Abnormal fMRI activation pattern during story listening in individuals with Down syndrome. / Reynolds Losin, Elizabeth A.; Rivera, Susan M.; O'Hare, Elizabeth D.; Sowell, Elizabeth R.; Pinter, Joseph.

In: American Journal on Intellectual and Developmental Disabilities, Vol. 114, No. 5, 09.2009, p. 369-380.

Research output: Contribution to journalArticle

Reynolds Losin, Elizabeth A. ; Rivera, Susan M. ; O'Hare, Elizabeth D. ; Sowell, Elizabeth R. ; Pinter, Joseph. / Abnormal fMRI activation pattern during story listening in individuals with Down syndrome. In: American Journal on Intellectual and Developmental Disabilities. 2009 ; Vol. 114, No. 5. pp. 369-380.
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