Abnormal development of retinogeniculate X axons in strabismic cats: a possible substrate for visual dysfunction

P. E. Garraghty, A. W. Roe, Y. M. Chino, M. Sur

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Rearing cats with surgically induced esotropia results in a number of structural and functional abnormalities in the visual system. In the present experiments, we have studied the morphology of individual retinogeniculate X axons in esotropic cats using intracellular recording and staining techniques. After serially reconstructing stained axonal arbors, we find that some X axon terminations in A-laminae of the lateral geniculate nucleus (LGN) have larger volumes and lower bouton densities than normal. This is true for X axons projecting from both the deviated and the non-deviated eye. It is possible that these abnormalities in morphological development contribute to the disruptions in signal transfer that has been observed in X-cells in the LGN of esotropic cats.

Original languageEnglish (US)
Pages (from-to)223-226
Number of pages4
JournalNeuroscience Letters
Volume165
Issue number1-2
DOIs
StatePublished - Jan 3 1994

Keywords

  • Esotropic cat
  • Retinogeniculate X axon

ASJC Scopus subject areas

  • Neuroscience(all)

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