Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin

Pietro De Togni, Joseph Goellner, Nancy H. Ruddle, Philip R. Streeter, Andrea Fick, Sanjeev Mariathasan, Stacy C. Smith, Rebecca Carlson, Laurie P. Shornick, Jena Strauss-Schoenberger, John H. Russell, Robert Karr, David D. Chaplint

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Mice rendered deficient in lymphotoxin (LT) by gene targeting in embryonic stem cells have no morphologically detectable lymph nodes or Peyer's patches, although development of the thymus appears normal. Within the white pulp of the spleen, there is failure of normal segregation of B and T cells. Spleen and peripheral blood contain CD4+CD8~ and CD4~CD8+ T cells in a normal ratio, and both T cell subsets have an apparently normal lytic function. Lymphocytes positive for immunoglobulin M are present in increased numbers in both the spleen and peripheral blood. These data suggest an essential role for LT in the normal development of peripheral lymphoid organs.

Original languageEnglish (US)
Pages (from-to)2007-2014
Number of pages8
JournalJournal of Immunology
Volume192
Issue number5
DOIs
StatePublished - Mar 1 2014

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    De Togni, P., Goellner, J., Ruddle, N. H., Streeter, P. R., Fick, A., Mariathasan, S., Smith, S. C., Carlson, R., Shornick, L. P., Strauss-Schoenberger, J., Russell, J. H., Karr, R., & Chaplint, D. D. (2014). Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin. Journal of Immunology, 192(5), 2007-2014. https://doi.org/10.1126/science.8171322