Abnormal cerebellar morphometry in abstinent adolescent marijuana users

Krista Lisdahl Medina, Bonnie Nagel, Susan F. Tapert

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

Functional neuroimaging data from adults have, in general, revealed frontocerebellar dysfunction associated with acute and chronic marijuana (MJ) use. The goal of this study was to characterize cerebellar volume in adolescent chronic MJ users following 1 month of monitored abstinence. Participants were MJ users (n=16) and controls (n=16) aged 16-18. years. Extensive exclusionary criteria included history of psychiatric or neurologic disorders. Drug use history, neuropsychological data, and structural brain scans were collected after 28. days of monitored abstinence. Trained research staff defined cerebellar volumes (including three cerebellar vermis lobes and both cerebellar hemispheres) on high-resolution T1-weighted magnetic resonance images. Adolescent MJ users demonstrated significantly larger inferior posterior (lobules VIII-X) vermis volume than controls, above and beyond effects of lifetime alcohol and other drug use, gender, and intracranial volume. Larger vermis volumes were associated with poorer executive functioning. Following 1 month of abstinence, adolescent MJ users had significantly larger posterior cerebellar vermis volumes than non-using controls. These greater volumes are suggested to be pathological based on linkage to poorer executive functioning. Longitudinal studies are needed to examine typical cerebellar development during adolescence and the influence of marijuana use.

Original languageEnglish (US)
Pages (from-to)152-159
Number of pages8
JournalPsychiatry Research - Neuroimaging
Volume182
Issue number2
DOIs
StatePublished - May 2010

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Cannabis
Functional Neuroimaging
Nervous System Diseases
Pharmaceutical Preparations
Psychiatry
Longitudinal Studies
Magnetic Resonance Spectroscopy
Alcohols
Brain
Research

Keywords

  • Adolescents
  • Cannabis
  • Cerebellum
  • Marijuana
  • MRI
  • Vermis

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Radiology Nuclear Medicine and imaging
  • Neuroscience (miscellaneous)

Cite this

Abnormal cerebellar morphometry in abstinent adolescent marijuana users. / Medina, Krista Lisdahl; Nagel, Bonnie; Tapert, Susan F.

In: Psychiatry Research - Neuroimaging, Vol. 182, No. 2, 05.2010, p. 152-159.

Research output: Contribution to journalArticle

Medina, Krista Lisdahl ; Nagel, Bonnie ; Tapert, Susan F. / Abnormal cerebellar morphometry in abstinent adolescent marijuana users. In: Psychiatry Research - Neuroimaging. 2010 ; Vol. 182, No. 2. pp. 152-159.
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