Abnormal anterior cingulum integrity in bipolar disorder determined through diffusion tensor imaging

Fei Wang, Marcel Jackowski, Jessica H. Kalmar, Lara G. Chepenik, Karen Tie, Maolin Qiu, Gaolang Gong, Brian P. Pittman, Monique M. Jones, Maulik P. Shah, Linda Spencer, Xenophon Papademetris, R. Todd Constable, Hilary P. Blumberg

Research output: Contribution to journalArticlepeer-review

92 Scopus citations


Background: Convergent evidence implicates white matter abnormalities in bipolar disorder. The cingulum is an important candidate structure for study in bipolar disorder as it provides substantial white matter connections within the corticolimbic neural system that subserves emotional regulation involved in the disorder. Aims: To test the hypothesis that bipolar disorder is associated with abnormal white matter integrity in the cingulum. Method: Fractional anisotropy in the anterior and posterior cingulum was compared between 42 participants with bipolar disorder and 42 healthy participants using diffusion tensor imaging. Results: Fractional anisotropy was significantly decreased in the anterior cingulum in the bipolar disorder group compared with the healthy group (P=0.003); however, fractional anisotropy in the posterior cingulum did not differ significantly between groups. Conclusions: Our findings demonstrate abnormalities in the structural integrity of the anterior cingulum in bipolar disorder. They extend evidence that supports involvement of the neural system comprising the anterior cinguiate cortex and its corticolimbic gray matter connection sites in bipolar disorder to implicate abnormalities in the white matter connections within the system provided by the cingulum.

Original languageEnglish (US)
Pages (from-to)126-129
Number of pages4
JournalBritish Journal of Psychiatry
Issue number2
StatePublished - Aug 2008
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health


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