Aberrations of MYC are a common event in B-cell prolymphocytic leukemia

Ellen Flatley, Andy Chen, Xiangrong Zhao, Elaine S. Jaffe, Jennifer Dunlap, Stefania Pittaluga, Shahed Abdullah, Susan Olson, Stephen Spurgeon, Guang Fan

Research output: Contribution to journalArticle

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Abstract

Objectives: B-cell prolymphocytic leukemia (B-PLL) remains a controversial entity, and its molecular pathogenesis is largely unknown. Patients are older, typically having marked lymphocytosis and splenomegaly in the absence of lymphadenopathy. It is defined as a mature B-cell leukemia with more than 55% circulating prolymphocytes. Leukemic mantle cell lymphoma and chronic lymphocytic leukemia in prolymphocytic transformation must be excluded.

Methods: Case archives were retrospectively reviewed for B-PLL in patients without a previous diagnosis of chronic lymphocytic leukemia or other B-cell neoplasm.

Results: We identified six cases of B-PLL with available cytogenetic data, five of which showed evidence of aberrations in MYC. Three cases showed additional signals for the MYC gene by fluorescence in situ hybridization (FISH), and two cases demonstrated t(8;14)MYC/IGH by karyotyping or FISH. High levels of MYC protein expression were detected in all cases tested with MYC aberrations.

Conclusions: These results suggest that deregulation of MYC plays an important role in the pathogenesis of B-PLL and expands the spectrum of B-cell neoplasms associated with aberrations of MYC.

Original languageEnglish (US)
Pages (from-to)347-354
Number of pages8
JournalAmerican Journal of Clinical Pathology
Volume142
Issue number3
DOIs
StatePublished - Sep 1 2014

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B-Cell Prolymphocytic Leukemia
B-Cell Chronic Lymphocytic Leukemia
Fluorescence In Situ Hybridization
B-Lymphocytes
B-Cell Leukemia
Mantle-Cell Lymphoma
Lymphocytosis
Karyotyping
Splenomegaly
Cytogenetics
Neoplasms
Genes
Proteins

Keywords

  • Cytogenetics
  • FISH
  • Leukemia
  • MYC
  • Prolymphocytic leukemia

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Aberrations of MYC are a common event in B-cell prolymphocytic leukemia. / Flatley, Ellen; Chen, Andy; Zhao, Xiangrong; Jaffe, Elaine S.; Dunlap, Jennifer; Pittaluga, Stefania; Abdullah, Shahed; Olson, Susan; Spurgeon, Stephen; Fan, Guang.

In: American Journal of Clinical Pathology, Vol. 142, No. 3, 01.09.2014, p. 347-354.

Research output: Contribution to journalArticle

Flatley, Ellen ; Chen, Andy ; Zhao, Xiangrong ; Jaffe, Elaine S. ; Dunlap, Jennifer ; Pittaluga, Stefania ; Abdullah, Shahed ; Olson, Susan ; Spurgeon, Stephen ; Fan, Guang. / Aberrations of MYC are a common event in B-cell prolymphocytic leukemia. In: American Journal of Clinical Pathology. 2014 ; Vol. 142, No. 3. pp. 347-354.
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