Aberrant signaling pathways in meningiomas

Brian T. Ragel, Randy L. Jensen

Research output: Contribution to journalReview article

43 Scopus citations

Abstract

In this article, we provide a brief description of the current understanding of aberrant signaling pathways in meningiomas. Cell signaling pathways are responsible for cellular differentiation, development, growth, growth inhibition, and death. In fact, signaling pathways can affect multiple intracellular functions, including those responsible for development, angiogenesis, and apoptosis. Ultimately, a further understanding of the signaling pathways involved in meningioma tumorigenesis will lead to the development and application of novel molecular treatments, such as small molecule inhibitors or interfering ribonucleic acid technologies.

Original languageEnglish (US)
Pages (from-to)315-324
Number of pages10
JournalJournal of Neuro-Oncology
Volume99
Issue number3
DOIs
StatePublished - Sep 1 2010

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Keywords

  • Cell signal pathways
  • Meningioma
  • Merlin
  • Protein 4.1B

ASJC Scopus subject areas

  • Oncology
  • Neurology
  • Clinical Neurology
  • Cancer Research

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