Aberrant estradiol flare despite gonadotropin-releasing hormone-agonist- induced suppression is associated with impaired implantation

A. S. Penzias; G. Lee; D. B. Seifer; F. N. Shamma; A. H. DeCherney; R. H. Reindollar; E. E. Jones

doi:10.1016/s0015-0282(16)56595-9

Aberrant estradiol flare despite gonadotropin-releasing hormone-agonist- induced suppression is associated with impaired implantation

A. S. Penzias, G. Lee, D. B. Seifer, F. N. Shamma, A. H. DeCherney, R. H. Reindollar, E. E. Jones

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Our results confirm the previous report that rapid suppression by GnRH-a is favorable relative to delayed suppression (1). They further indicate that the pattern of E₂ production during GnRH-a-induced ovarian suppression may be predictive of cycle outcome. We suggest that imperfect pituitary suppression of bioactive LH as indicated by an aberrant rise in E₂ during GnRH-a down-regulation may compromise oocyte quality and ultimately impair implantation. Further study of follicular phase E₂ response to GnRH-a suppression may provide a prognostic marker for implantation.

Original language	English (US)
Pages (from-to)	558-560
Number of pages	3
Journal	Fertility and sterility
Volume	61
Issue number	3
DOIs	https://doi.org/10.1016/s0015-0282(16)56595-9
State	Published - 1994
Externally published	Yes

Keywords

Bioactive gonadotropins
fertilization in vitro
immunoactive gonadotropins

ASJC Scopus subject areas

Reproductive Medicine
Obstetrics and Gynecology

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10.1016/s0015-0282(16)56595-9

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title = "Aberrant estradiol flare despite gonadotropin-releasing hormone-agonist- induced suppression is associated with impaired implantation",

abstract = "Our results confirm the previous report that rapid suppression by GnRH-a is favorable relative to delayed suppression (1). They further indicate that the pattern of E2 production during GnRH-a-induced ovarian suppression may be predictive of cycle outcome. We suggest that imperfect pituitary suppression of bioactive LH as indicated by an aberrant rise in E2 during GnRH-a down-regulation may compromise oocyte quality and ultimately impair implantation. Further study of follicular phase E2 response to GnRH-a suppression may provide a prognostic marker for implantation.",

keywords = "Bioactive gonadotropins, fertilization in vitro, immunoactive gonadotropins",

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year = "1994",

doi = "10.1016/s0015-0282(16)56595-9",

language = "English (US)",

volume = "61",

pages = "558--560",

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T1 - Aberrant estradiol flare despite gonadotropin-releasing hormone-agonist- induced suppression is associated with impaired implantation

AU - Penzias, A. S.

AU - Lee, G.

AU - Seifer, D. B.

AU - Shamma, F. N.

AU - DeCherney, A. H.

AU - Reindollar, R. H.

AU - Jones, E. E.

PY - 1994

Y1 - 1994

N2 - Our results confirm the previous report that rapid suppression by GnRH-a is favorable relative to delayed suppression (1). They further indicate that the pattern of E2 production during GnRH-a-induced ovarian suppression may be predictive of cycle outcome. We suggest that imperfect pituitary suppression of bioactive LH as indicated by an aberrant rise in E2 during GnRH-a down-regulation may compromise oocyte quality and ultimately impair implantation. Further study of follicular phase E2 response to GnRH-a suppression may provide a prognostic marker for implantation.

AB - Our results confirm the previous report that rapid suppression by GnRH-a is favorable relative to delayed suppression (1). They further indicate that the pattern of E2 production during GnRH-a-induced ovarian suppression may be predictive of cycle outcome. We suggest that imperfect pituitary suppression of bioactive LH as indicated by an aberrant rise in E2 during GnRH-a down-regulation may compromise oocyte quality and ultimately impair implantation. Further study of follicular phase E2 response to GnRH-a suppression may provide a prognostic marker for implantation.

KW - Bioactive gonadotropins

KW - fertilization in vitro

KW - immunoactive gonadotropins

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M3 - Article

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AN - SCOPUS:0028210080

SN - 0015-0282

VL - 61

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JO - Fertility and sterility

JF - Fertility and sterility

IS - 3

ER -

Aberrant estradiol flare despite gonadotropin-releasing hormone-agonist- induced suppression is associated with impaired implantation

Abstract

Keywords

ASJC Scopus subject areas

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