Aberrant estradiol flare despite gonadotropin-releasing hormone-agonist- induced suppression is associated with impaired implantation

A. S. Penzias, G. Lee, D. B. Seifer, F. N. Shamma, A. H. DeCherney, R. H. Reindollar, E. E. Jones

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Our results confirm the previous report that rapid suppression by GnRH-a is favorable relative to delayed suppression (1). They further indicate that the pattern of E2 production during GnRH-a-induced ovarian suppression may be predictive of cycle outcome. We suggest that imperfect pituitary suppression of bioactive LH as indicated by an aberrant rise in E2 during GnRH-a down-regulation may compromise oocyte quality and ultimately impair implantation. Further study of follicular phase E2 response to GnRH-a suppression may provide a prognostic marker for implantation.

Original languageEnglish (US)
Pages (from-to)558-560
Number of pages3
JournalFertility and sterility
Volume61
Issue number3
StatePublished - Jan 1 1994

Keywords

  • Bioactive gonadotropins
  • fertilization in vitro
  • immunoactive gonadotropins

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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    Penzias, A. S., Lee, G., Seifer, D. B., Shamma, F. N., DeCherney, A. H., Reindollar, R. H., & Jones, E. E. (1994). Aberrant estradiol flare despite gonadotropin-releasing hormone-agonist- induced suppression is associated with impaired implantation. Fertility and sterility, 61(3), 558-560.