Aberrant estradiol flare despite gonadotropin-releasing hormone-agonist- induced suppression is associated with impaired implantation

A. S. Penzias, G. Lee, David Seifer, F. N. Shamma, A. H. DeCherney, R. H. Reindollar, E. E. Jones

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Our results confirm the previous report that rapid suppression by GnRH-a is favorable relative to delayed suppression (1). They further indicate that the pattern of E2 production during GnRH-a-induced ovarian suppression may be predictive of cycle outcome. We suggest that imperfect pituitary suppression of bioactive LH as indicated by an aberrant rise in E2 during GnRH-a down-regulation may compromise oocyte quality and ultimately impair implantation. Further study of follicular phase E2 response to GnRH-a suppression may provide a prognostic marker for implantation.

Original languageEnglish (US)
Pages (from-to)558-560
Number of pages3
JournalFertility and Sterility
Volume61
Issue number3
StatePublished - 1994
Externally publishedYes

Fingerprint

Gonadotropin-Releasing Hormone
Estradiol
Follicular Phase
Oocytes
Down-Regulation

Keywords

  • Bioactive gonadotropins
  • fertilization in vitro
  • immunoactive gonadotropins

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Penzias, A. S., Lee, G., Seifer, D., Shamma, F. N., DeCherney, A. H., Reindollar, R. H., & Jones, E. E. (1994). Aberrant estradiol flare despite gonadotropin-releasing hormone-agonist- induced suppression is associated with impaired implantation. Fertility and Sterility, 61(3), 558-560.

Aberrant estradiol flare despite gonadotropin-releasing hormone-agonist- induced suppression is associated with impaired implantation. / Penzias, A. S.; Lee, G.; Seifer, David; Shamma, F. N.; DeCherney, A. H.; Reindollar, R. H.; Jones, E. E.

In: Fertility and Sterility, Vol. 61, No. 3, 1994, p. 558-560.

Research output: Contribution to journalArticle

Penzias, AS, Lee, G, Seifer, D, Shamma, FN, DeCherney, AH, Reindollar, RH & Jones, EE 1994, 'Aberrant estradiol flare despite gonadotropin-releasing hormone-agonist- induced suppression is associated with impaired implantation', Fertility and Sterility, vol. 61, no. 3, pp. 558-560.
Penzias, A. S. ; Lee, G. ; Seifer, David ; Shamma, F. N. ; DeCherney, A. H. ; Reindollar, R. H. ; Jones, E. E. / Aberrant estradiol flare despite gonadotropin-releasing hormone-agonist- induced suppression is associated with impaired implantation. In: Fertility and Sterility. 1994 ; Vol. 61, No. 3. pp. 558-560.
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