Abdominal body composition measured by quantitative computed tomography and risk of non-spine fractures

The Osteoporotic Fractures in Men (MrOS) study

Y. Sheu, Lynn Marshall, K. F. Holton, P. Caserotti, R. M. Boudreau, E. S. Strotmeyer, P. M. Cawthon, J. A. Cauley

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The effect of abdominal adiposity and muscle on fracture is unclear in older men; therefore, we examined the association among 749 men aged 65+. Among various adipose tissues and muscle groups, lower psoas muscle volume and higher fatty infiltration of abdominal muscle contribute to higher fracture risk independent of BMD. Introduction: The association of abdominal adiposity and muscle composition with incident fracture is unclear, especially in older men. Therefore, we examined the relationship of subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT), abdominal intermuscular adipose tissue (IMAT), and muscle volume with incident non-spine fractures among 749 men aged 65 and older. Methods: A case-cohort study design was used with a total of 252 fracture cases and 497 non-cases. We measured volumes (in centimeters) of adipose and muscle tissues obtained from quantitative computed tomography scan at the L4-5 intervertebral space. Three groups of muscle and IMAT were evaluated: total abdominal, psoas, and paraspinal. Cox proportional hazards regression with a robust variance estimator was used to estimate the hazard ratio (HR) of non-spine fractures per standard deviation (SD) increase in the abdominal body composition measures. The mean age among men in the random subcohort was 74.2 ± 6.1 years, and the average follow-up time was 5.2 ± 1.1 years. Results: After adjusting for age, race, clinic site, percent body fat, and femoral neck bone mineral density (BMD), no significant relationship was found between incident fractures and SAT or VAT. One SD increase in muscle volume at the psoas, but not paraspinal, was associated with 28 % lower fracture risk (95 % CI = 0.55-0.95). When IMAT models were further adjusted for corresponding muscle volumes, only abdominal IMAT was significantly associated with fracture risk (HR = 1.30 (95 % CI = 1.04-1.63)). Conclusion: Our findings suggest that lower total psoas muscle volume and higher IMAT of the total abdominal muscle contribute to higher fracture risk in older men independent of BMD.

Original languageEnglish (US)
Pages (from-to)2231-2241
Number of pages11
JournalOsteoporosis International
Volume24
Issue number8
DOIs
StatePublished - Aug 2013

Fingerprint

Osteoporotic Fractures
Body Composition
Adipose Tissue
Abdominal Muscles
Tomography
Muscles
Bone Density
Psoas Muscles
Abdominal Fat
Intra-Abdominal Fat
Subcutaneous Fat
Adiposity
Body Weights and Measures
Femur Neck
Cohort Studies
Odds Ratio

Keywords

  • Adipose tissue
  • Fracture
  • Intermuscular fat
  • Muscle

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Abdominal body composition measured by quantitative computed tomography and risk of non-spine fractures : The Osteoporotic Fractures in Men (MrOS) study. / Sheu, Y.; Marshall, Lynn; Holton, K. F.; Caserotti, P.; Boudreau, R. M.; Strotmeyer, E. S.; Cawthon, P. M.; Cauley, J. A.

In: Osteoporosis International, Vol. 24, No. 8, 08.2013, p. 2231-2241.

Research output: Contribution to journalArticle

Sheu, Y. ; Marshall, Lynn ; Holton, K. F. ; Caserotti, P. ; Boudreau, R. M. ; Strotmeyer, E. S. ; Cawthon, P. M. ; Cauley, J. A. / Abdominal body composition measured by quantitative computed tomography and risk of non-spine fractures : The Osteoporotic Fractures in Men (MrOS) study. In: Osteoporosis International. 2013 ; Vol. 24, No. 8. pp. 2231-2241.
@article{c6dc865378984679bcbf08566c2ace7a,
title = "Abdominal body composition measured by quantitative computed tomography and risk of non-spine fractures: The Osteoporotic Fractures in Men (MrOS) study",
abstract = "The effect of abdominal adiposity and muscle on fracture is unclear in older men; therefore, we examined the association among 749 men aged 65+. Among various adipose tissues and muscle groups, lower psoas muscle volume and higher fatty infiltration of abdominal muscle contribute to higher fracture risk independent of BMD. Introduction: The association of abdominal adiposity and muscle composition with incident fracture is unclear, especially in older men. Therefore, we examined the relationship of subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT), abdominal intermuscular adipose tissue (IMAT), and muscle volume with incident non-spine fractures among 749 men aged 65 and older. Methods: A case-cohort study design was used with a total of 252 fracture cases and 497 non-cases. We measured volumes (in centimeters) of adipose and muscle tissues obtained from quantitative computed tomography scan at the L4-5 intervertebral space. Three groups of muscle and IMAT were evaluated: total abdominal, psoas, and paraspinal. Cox proportional hazards regression with a robust variance estimator was used to estimate the hazard ratio (HR) of non-spine fractures per standard deviation (SD) increase in the abdominal body composition measures. The mean age among men in the random subcohort was 74.2 ± 6.1 years, and the average follow-up time was 5.2 ± 1.1 years. Results: After adjusting for age, race, clinic site, percent body fat, and femoral neck bone mineral density (BMD), no significant relationship was found between incident fractures and SAT or VAT. One SD increase in muscle volume at the psoas, but not paraspinal, was associated with 28 {\%} lower fracture risk (95 {\%} CI = 0.55-0.95). When IMAT models were further adjusted for corresponding muscle volumes, only abdominal IMAT was significantly associated with fracture risk (HR = 1.30 (95 {\%} CI = 1.04-1.63)). Conclusion: Our findings suggest that lower total psoas muscle volume and higher IMAT of the total abdominal muscle contribute to higher fracture risk in older men independent of BMD.",
keywords = "Adipose tissue, Fracture, Intermuscular fat, Muscle",
author = "Y. Sheu and Lynn Marshall and Holton, {K. F.} and P. Caserotti and Boudreau, {R. M.} and Strotmeyer, {E. S.} and Cawthon, {P. M.} and Cauley, {J. A.}",
year = "2013",
month = "8",
doi = "10.1007/s00198-013-2322-9",
language = "English (US)",
volume = "24",
pages = "2231--2241",
journal = "Osteoporosis International",
issn = "0937-941X",
publisher = "Springer London",
number = "8",

}

TY - JOUR

T1 - Abdominal body composition measured by quantitative computed tomography and risk of non-spine fractures

T2 - The Osteoporotic Fractures in Men (MrOS) study

AU - Sheu, Y.

AU - Marshall, Lynn

AU - Holton, K. F.

AU - Caserotti, P.

AU - Boudreau, R. M.

AU - Strotmeyer, E. S.

AU - Cawthon, P. M.

AU - Cauley, J. A.

PY - 2013/8

Y1 - 2013/8

N2 - The effect of abdominal adiposity and muscle on fracture is unclear in older men; therefore, we examined the association among 749 men aged 65+. Among various adipose tissues and muscle groups, lower psoas muscle volume and higher fatty infiltration of abdominal muscle contribute to higher fracture risk independent of BMD. Introduction: The association of abdominal adiposity and muscle composition with incident fracture is unclear, especially in older men. Therefore, we examined the relationship of subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT), abdominal intermuscular adipose tissue (IMAT), and muscle volume with incident non-spine fractures among 749 men aged 65 and older. Methods: A case-cohort study design was used with a total of 252 fracture cases and 497 non-cases. We measured volumes (in centimeters) of adipose and muscle tissues obtained from quantitative computed tomography scan at the L4-5 intervertebral space. Three groups of muscle and IMAT were evaluated: total abdominal, psoas, and paraspinal. Cox proportional hazards regression with a robust variance estimator was used to estimate the hazard ratio (HR) of non-spine fractures per standard deviation (SD) increase in the abdominal body composition measures. The mean age among men in the random subcohort was 74.2 ± 6.1 years, and the average follow-up time was 5.2 ± 1.1 years. Results: After adjusting for age, race, clinic site, percent body fat, and femoral neck bone mineral density (BMD), no significant relationship was found between incident fractures and SAT or VAT. One SD increase in muscle volume at the psoas, but not paraspinal, was associated with 28 % lower fracture risk (95 % CI = 0.55-0.95). When IMAT models were further adjusted for corresponding muscle volumes, only abdominal IMAT was significantly associated with fracture risk (HR = 1.30 (95 % CI = 1.04-1.63)). Conclusion: Our findings suggest that lower total psoas muscle volume and higher IMAT of the total abdominal muscle contribute to higher fracture risk in older men independent of BMD.

AB - The effect of abdominal adiposity and muscle on fracture is unclear in older men; therefore, we examined the association among 749 men aged 65+. Among various adipose tissues and muscle groups, lower psoas muscle volume and higher fatty infiltration of abdominal muscle contribute to higher fracture risk independent of BMD. Introduction: The association of abdominal adiposity and muscle composition with incident fracture is unclear, especially in older men. Therefore, we examined the relationship of subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT), abdominal intermuscular adipose tissue (IMAT), and muscle volume with incident non-spine fractures among 749 men aged 65 and older. Methods: A case-cohort study design was used with a total of 252 fracture cases and 497 non-cases. We measured volumes (in centimeters) of adipose and muscle tissues obtained from quantitative computed tomography scan at the L4-5 intervertebral space. Three groups of muscle and IMAT were evaluated: total abdominal, psoas, and paraspinal. Cox proportional hazards regression with a robust variance estimator was used to estimate the hazard ratio (HR) of non-spine fractures per standard deviation (SD) increase in the abdominal body composition measures. The mean age among men in the random subcohort was 74.2 ± 6.1 years, and the average follow-up time was 5.2 ± 1.1 years. Results: After adjusting for age, race, clinic site, percent body fat, and femoral neck bone mineral density (BMD), no significant relationship was found between incident fractures and SAT or VAT. One SD increase in muscle volume at the psoas, but not paraspinal, was associated with 28 % lower fracture risk (95 % CI = 0.55-0.95). When IMAT models were further adjusted for corresponding muscle volumes, only abdominal IMAT was significantly associated with fracture risk (HR = 1.30 (95 % CI = 1.04-1.63)). Conclusion: Our findings suggest that lower total psoas muscle volume and higher IMAT of the total abdominal muscle contribute to higher fracture risk in older men independent of BMD.

KW - Adipose tissue

KW - Fracture

KW - Intermuscular fat

KW - Muscle

UR - http://www.scopus.com/inward/record.url?scp=84880323577&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84880323577&partnerID=8YFLogxK

U2 - 10.1007/s00198-013-2322-9

DO - 10.1007/s00198-013-2322-9

M3 - Article

VL - 24

SP - 2231

EP - 2241

JO - Osteoporosis International

JF - Osteoporosis International

SN - 0937-941X

IS - 8

ER -