TY - JOUR
T1 - Abdominal aortic aneurysms
T2 - Cost-effectiveness of elective endovascular and open surgical repair
AU - Bosch, Johanna L.
AU - Kaufman, John A.
AU - Beinfeld, Molly T.
AU - Adriaensen, Miraude E.A.P.M.
AU - Brewster, David C.
AU - Gazelle, G. Scott
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2002/11/1
Y1 - 2002/11/1
N2 - PURPOSE: To evaluate the cost-effectiveness of elective endovascular and open surgical repair of infrarenal abdominal aortic aneurysms (AAAs) by taking into account short- and long-term outcomes. MATERIALS AND METHODS: A Markov decision model was developed to evaluate quality-adjusted life-years (QALYs) and lifetime costs of endovascular and open surgical repair. The incremental cost-effectiveness ratio (CER) was calculated for endovascular repair relative to open surgery in a cohort of 70-year-old men with an AAA between 5 and 6 cm in diameter. Clinically effectiveness data were derived from the literature. Cost data were derived from Medicare reimbursement rates, the hospital database, and the literature. One- and multiple-way sensitivity analyses were performed on uncertain model parameters. Costs were converted to year 2000 U.S. dollars; future costs and outcomes were discounted at 3%. RESULTS: The incremental CER of endovascular repair was $9,905 per QALY. QALYs and lifetime costs were higher for endovascular repair than for open surgery (6.74 vs 6.52 and $39,785 vs $37,606, respectively). In sensitivity analyses, the incremental CER was insensitive to immediate conversion rate and procedure mortality rate. The incremental CER was sensitive (ie, more than $75,000 per QALY or endovascular repair was ruled out by dominance) to systemic-remote complications, long-term failures, and ruptures. CONCLUSION: The results suggest that endovascular repair is a cost-effective alternative compared with open surgery for the elective repair of AAA. The benefits and cost-effectiveness are highly dependent on uncertain outcomes, however, particularly long-term failure and rupture rates.
AB - PURPOSE: To evaluate the cost-effectiveness of elective endovascular and open surgical repair of infrarenal abdominal aortic aneurysms (AAAs) by taking into account short- and long-term outcomes. MATERIALS AND METHODS: A Markov decision model was developed to evaluate quality-adjusted life-years (QALYs) and lifetime costs of endovascular and open surgical repair. The incremental cost-effectiveness ratio (CER) was calculated for endovascular repair relative to open surgery in a cohort of 70-year-old men with an AAA between 5 and 6 cm in diameter. Clinically effectiveness data were derived from the literature. Cost data were derived from Medicare reimbursement rates, the hospital database, and the literature. One- and multiple-way sensitivity analyses were performed on uncertain model parameters. Costs were converted to year 2000 U.S. dollars; future costs and outcomes were discounted at 3%. RESULTS: The incremental CER of endovascular repair was $9,905 per QALY. QALYs and lifetime costs were higher for endovascular repair than for open surgery (6.74 vs 6.52 and $39,785 vs $37,606, respectively). In sensitivity analyses, the incremental CER was insensitive to immediate conversion rate and procedure mortality rate. The incremental CER was sensitive (ie, more than $75,000 per QALY or endovascular repair was ruled out by dominance) to systemic-remote complications, long-term failures, and ruptures. CONCLUSION: The results suggest that endovascular repair is a cost-effective alternative compared with open surgery for the elective repair of AAA. The benefits and cost-effectiveness are highly dependent on uncertain outcomes, however, particularly long-term failure and rupture rates.
KW - Aneurysm, abdominal
KW - Aorta, grafts and prostheses
KW - Aorta, interventional procedures
KW - Cost-effectiveness
KW - Economics, medical
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U2 - 10.1148/radiol.2252011687
DO - 10.1148/radiol.2252011687
M3 - Article
C2 - 12409564
AN - SCOPUS:0036830217
SN - 0033-8419
VL - 225
SP - 337
EP - 344
JO - RADIOLOGY
JF - RADIOLOGY
IS - 2
ER -