A weakly pathogenic Rauscher spleen focus-forming virus mutant that lacks the carboxyl-terminal membrane anchor of its envelope glycoprotein

Curtis Machida, R. K. Bestwick, David Kabat

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A mutant Rauscher spleen focus-forming virus (mutant 4-3) that causes mild splenic erythroblastoma in mice has a 44-base-pair deletion in the 3' region of its envelope glycoprotein (env) gene. The encoded glycoprotein terminates prematurely, lacks a hydrophobic membrane anchor, and has a shortened intracellular lifespan. An active site for causing erythroblast proliferation may occur in the undamaged amino-terminal domain of the env glycoprotein.

Original languageEnglish (US)
Pages (from-to)990-993
Number of pages4
JournalJournal of Virology
Volume53
Issue number3
StatePublished - 1985

Fingerprint

Spleen Focus-Forming Viruses
glycoproteins
Glycoproteins
spleen
env Gene Products
env Genes
Erythroblasts
viruses
mutants
Membranes
erythroblasts
Base Pairing
Catalytic Domain
active sites
mice
genes

ASJC Scopus subject areas

  • Immunology

Cite this

A weakly pathogenic Rauscher spleen focus-forming virus mutant that lacks the carboxyl-terminal membrane anchor of its envelope glycoprotein. / Machida, Curtis; Bestwick, R. K.; Kabat, David.

In: Journal of Virology, Vol. 53, No. 3, 1985, p. 990-993.

Research output: Contribution to journalArticle

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