A weakly pathogenic Rauscher spleen focus-forming virus mutant that lacks the carboxyl-terminal membrane anchor of its envelope glycoprotein

C. A. Machida, R. K. Bestwick, D. Kabat

Research output: Contribution to journalArticle

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Abstract

A mutant Rauscher spleen focus-forming virus (mutant 4-3) that causes mild splenic erythroblastoma in mice has a 44-base-pair deletion in the 3' region of its envelope glycoprotein (env) gene. The encoded glycoprotein terminates prematurely, lacks a hydrophobic membrane anchor, and has a shortened intracellular lifespan. An active site for causing erythroblast proliferation may occur in the undamaged amino-terminal domain of the env glycoprotein.

Original languageEnglish (US)
Pages (from-to)990-993
Number of pages4
JournalJournal of virology
Volume53
Issue number3
StatePublished - Jan 1 1985

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ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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