A WAVE-1 and WRP signaling complex regulates spine density, synaptic plasticity, and memory

Scott H. Soderling, Eric S. Guire, Stefanie Kaech-Petrie, Jon White, Fang Zhang, Kevin Schutz, Lorene K. Langeberg, Gary Banker, Jacob Raber, John D. Scott

Research output: Contribution to journalArticle

141 Citations (Scopus)

Abstract

The scaffolding protein WAVE-1 (Wiskott-Aldrich syndrome protein family member 1) directs signals from the GTPase Rac through the Arp2/3 complex to facilitate neuronal actin remodeling. The WAVE-associated GTPase activating protein called WRP is implicated in human mental retardation, and WAVE-1 knock-out mice have altered behavior. Neuronal time-lapse imaging, behavioral analyses, and electrophysiological recordings from genetically modified mice were used to show that WAVE-1 signaling complexes control aspects of neuronal morphogenesis and synaptic plasticity. Gene targeting experiments in mice demonstrate that WRP anchoring to WAVE-1 is a homeostatic mechanism that contributes to neuronal development and the fidelity of synaptic connectivity. This implies that signaling through WAVE-1 complexes is essential for neural plasticity and cognitive behavior.

Original languageEnglish (US)
Pages (from-to)355-365
Number of pages11
JournalJournal of Neuroscience
Volume27
Issue number2
DOIs
StatePublished - Jan 10 2007

Fingerprint

Neuronal Plasticity
Wiskott-Aldrich Syndrome Protein Family
Spine
Actin-Related Protein 2-3 Complex
Time-Lapse Imaging
GTPase-Activating Proteins
Gene Targeting
GTP Phosphohydrolases
Morphogenesis
Knockout Mice
Intellectual Disability
Actins

Keywords

  • Actin
  • Arp2/3
  • Dendritic spine
  • Synaptic plasticity
  • WAVE-1
  • WRP

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

A WAVE-1 and WRP signaling complex regulates spine density, synaptic plasticity, and memory. / Soderling, Scott H.; Guire, Eric S.; Kaech-Petrie, Stefanie; White, Jon; Zhang, Fang; Schutz, Kevin; Langeberg, Lorene K.; Banker, Gary; Raber, Jacob; Scott, John D.

In: Journal of Neuroscience, Vol. 27, No. 2, 10.01.2007, p. 355-365.

Research output: Contribution to journalArticle

Soderling, SH, Guire, ES, Kaech-Petrie, S, White, J, Zhang, F, Schutz, K, Langeberg, LK, Banker, G, Raber, J & Scott, JD 2007, 'A WAVE-1 and WRP signaling complex regulates spine density, synaptic plasticity, and memory', Journal of Neuroscience, vol. 27, no. 2, pp. 355-365. https://doi.org/10.1523/JNEUROSCI.3209-06.2006
Soderling, Scott H. ; Guire, Eric S. ; Kaech-Petrie, Stefanie ; White, Jon ; Zhang, Fang ; Schutz, Kevin ; Langeberg, Lorene K. ; Banker, Gary ; Raber, Jacob ; Scott, John D. / A WAVE-1 and WRP signaling complex regulates spine density, synaptic plasticity, and memory. In: Journal of Neuroscience. 2007 ; Vol. 27, No. 2. pp. 355-365.
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