A WAVE-1 and WRP signaling complex regulates spine density, synaptic plasticity, and memory

Scott H. Soderling, Eric S. Guire, Stefanie Kaech-Petrie, Jon White, Fang Zhang, Kevin Schutz, Lorene K. Langeberg, Gary Banker, Jacob Raber, John D. Scott

Research output: Contribution to journalArticle

144 Scopus citations

Abstract

The scaffolding protein WAVE-1 (Wiskott-Aldrich syndrome protein family member 1) directs signals from the GTPase Rac through the Arp2/3 complex to facilitate neuronal actin remodeling. The WAVE-associated GTPase activating protein called WRP is implicated in human mental retardation, and WAVE-1 knock-out mice have altered behavior. Neuronal time-lapse imaging, behavioral analyses, and electrophysiological recordings from genetically modified mice were used to show that WAVE-1 signaling complexes control aspects of neuronal morphogenesis and synaptic plasticity. Gene targeting experiments in mice demonstrate that WRP anchoring to WAVE-1 is a homeostatic mechanism that contributes to neuronal development and the fidelity of synaptic connectivity. This implies that signaling through WAVE-1 complexes is essential for neural plasticity and cognitive behavior.

Original languageEnglish (US)
Pages (from-to)355-365
Number of pages11
JournalJournal of Neuroscience
Volume27
Issue number2
DOIs
Publication statusPublished - Jan 10 2007

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Keywords

  • Actin
  • Arp2/3
  • Dendritic spine
  • Synaptic plasticity
  • WAVE-1
  • WRP

ASJC Scopus subject areas

  • Neuroscience(all)

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