A variety of tumours induced by the middle T antigen of polyoma virus in a transgenic mouse family

M. Rassoulzadegan, S. A. Courtneidge, R. Loubiere, P. El Baze, F. Cuzin

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

A transgenic mouse family expressing the middle T antigen of polyoma virus under control of the immunoglobulin heavy chain (IgE) enhancer showed the frequent occurrence of carcinomas in various organs, predominantly in females. Most frequently affected were the salivary and thyroid glands, but mammary tumours, liver haemangiomas and adenocarcinomas of unknown origin were also observed. In all tumours, the middle T antigen was found to be complexed with cellular tyrosine kinases. These results extend the range of tumour types associated with in vivo expression of middle T and with the subsequent deregulation of pp60(c-src) and related tyrosine kinases.

Original languageEnglish (US)
Pages (from-to)1507-1510
Number of pages4
JournalOncogene
Volume5
Issue number10
StatePublished - Nov 29 1990

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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    Rassoulzadegan, M., Courtneidge, S. A., Loubiere, R., El Baze, P., & Cuzin, F. (1990). A variety of tumours induced by the middle T antigen of polyoma virus in a transgenic mouse family. Oncogene, 5(10), 1507-1510.