A variety of tumours induced by the middle T antigen of polyoma virus in a transgenic mouse family

Minoo Rassoulzadegan, Sara Courtneidge, Robert Loubière, Philip El Baze, François Cuzin

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

A transgenic mouse family expressing the middle T antigen of polyoma virus under control of the immunoglobulin heavy chain (IgE) enhancer showed the frequent occurrence of carcinomas in various organs, predominantly in females. Most frequently affected were the salivary and thyroid glands, but mammary tumours, liver haemangiomas and adenocarcinomas of unknown origin were also observed. In all tumours, the middle T antigen was found to be complexed with cellular tyrosine kinases. These results extend the range of tumour types associated with in vivo expression of middle T and with the subsequent deregulation of pp60c-src and related tyrosine kinases.

Original languageEnglish (US)
Pages (from-to)1507-1510
Number of pages4
JournalOncogene
Volume5
Issue number10
StatePublished - Oct 1990
Externally publishedYes

Fingerprint

Polyomavirus
Viral Tumor Antigens
Transgenic Mice
Immunoglobulin Heavy Chains
src-Family Kinases
Hemangioma
Salivary Glands
Protein-Tyrosine Kinases
Immunoglobulin E
Neoplasms
Thyroid Gland
Adenocarcinoma
Breast Neoplasms
Carcinoma
Liver

ASJC Scopus subject areas

  • Molecular Biology
  • Cancer Research
  • Genetics

Cite this

Rassoulzadegan, M., Courtneidge, S., Loubière, R., El Baze, P., & Cuzin, F. (1990). A variety of tumours induced by the middle T antigen of polyoma virus in a transgenic mouse family. Oncogene, 5(10), 1507-1510.

A variety of tumours induced by the middle T antigen of polyoma virus in a transgenic mouse family. / Rassoulzadegan, Minoo; Courtneidge, Sara; Loubière, Robert; El Baze, Philip; Cuzin, François.

In: Oncogene, Vol. 5, No. 10, 10.1990, p. 1507-1510.

Research output: Contribution to journalArticle

Rassoulzadegan, M, Courtneidge, S, Loubière, R, El Baze, P & Cuzin, F 1990, 'A variety of tumours induced by the middle T antigen of polyoma virus in a transgenic mouse family', Oncogene, vol. 5, no. 10, pp. 1507-1510.
Rassoulzadegan, Minoo ; Courtneidge, Sara ; Loubière, Robert ; El Baze, Philip ; Cuzin, François. / A variety of tumours induced by the middle T antigen of polyoma virus in a transgenic mouse family. In: Oncogene. 1990 ; Vol. 5, No. 10. pp. 1507-1510.
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