Abstract
A transgenic mouse family expressing the middle T antigen of polyoma virus under control of the immunoglobulin heavy chain (IgE) enhancer showed the frequent occurrence of carcinomas in various organs, predominantly in females. Most frequently affected were the salivary and thyroid glands, but mammary tumours, liver haemangiomas and adenocarcinomas of unknown origin were also observed. In all tumours, the middle T antigen was found to be complexed with cellular tyrosine kinases. These results extend the range of tumour types associated with in vivo expression of middle T and with the subsequent deregulation of pp60c-src and related tyrosine kinases.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1507-1510 |
| Number of pages | 4 |
| Journal | Oncogene |
| Volume | 5 |
| Issue number | 10 |
| State | Published - Oct 1990 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Molecular Biology
- Cancer Research
- Genetics
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A variety of tumours induced by the middle T antigen of polyoma virus in a transgenic mouse family. / Rassoulzadegan, Minoo; Courtneidge, Sara; Loubière, Robert; El Baze, Philip; Cuzin, François.
In: Oncogene, Vol. 5, No. 10, 10.1990, p. 1507-1510.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A variety of tumours induced by the middle T antigen of polyoma virus in a transgenic mouse family
AU - Rassoulzadegan, Minoo
AU - Courtneidge, Sara
AU - Loubière, Robert
AU - El Baze, Philip
AU - Cuzin, François
PY - 1990/10
Y1 - 1990/10
N2 - A transgenic mouse family expressing the middle T antigen of polyoma virus under control of the immunoglobulin heavy chain (IgE) enhancer showed the frequent occurrence of carcinomas in various organs, predominantly in females. Most frequently affected were the salivary and thyroid glands, but mammary tumours, liver haemangiomas and adenocarcinomas of unknown origin were also observed. In all tumours, the middle T antigen was found to be complexed with cellular tyrosine kinases. These results extend the range of tumour types associated with in vivo expression of middle T and with the subsequent deregulation of pp60c-src and related tyrosine kinases.
AB - A transgenic mouse family expressing the middle T antigen of polyoma virus under control of the immunoglobulin heavy chain (IgE) enhancer showed the frequent occurrence of carcinomas in various organs, predominantly in females. Most frequently affected were the salivary and thyroid glands, but mammary tumours, liver haemangiomas and adenocarcinomas of unknown origin were also observed. In all tumours, the middle T antigen was found to be complexed with cellular tyrosine kinases. These results extend the range of tumour types associated with in vivo expression of middle T and with the subsequent deregulation of pp60c-src and related tyrosine kinases.
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UR - http://www.scopus.com/inward/citedby.url?scp=0025156088&partnerID=8YFLogxK
M3 - Article
C2 - 2123530
AN - SCOPUS:0025156088
VL - 5
SP - 1507
EP - 1510
JO - Oncogene
JF - Oncogene
SN - 0950-9232
IS - 10
ER -