A two-dimensional fingerprint nanoprobe based on black phosphorus for bio-SERS analysis and chemo-photothermal therapy

Zhiming Liu; Haolin Chen; Yali Jia; Wen Zhang; Henan Zhao; Wendong Fan; Wolun Zhang; Huiqing Zhong; Yirong Ni; Zhouyi Guo

doi:10.1039/c8nr05300f

A two-dimensional fingerprint nanoprobe based on black phosphorus for bio-SERS analysis and chemo-photothermal therapy

Zhiming Liu, Haolin Chen, Yali Jia, Wen Zhang, Henan Zhao, Wendong Fan, Wolun Zhang, Huiqing Zhong, Yirong Ni, Zhouyi Guo

Ophthalmology

Research output: Contribution to journal › Article › peer-review

67 Scopus citations

Abstract

Flake-shaped nanohybrids based on black phosphorus (BP) have been developed as multifunctional theranostic nanoplatforms for drug delivery, phototherapy and bioimaging. In this work, we report a facile strategy for fabrication of black phosphorus-Au nanoparticle hybrids (BP-AuNPs), which reveal an extraordinary near-infrared (NIR) photothermal transduction efficiency and drug delivery capacity. The applications of the nanocomposites as therapeutic agents for high-performance chemo-photothermal tumor therapy are accomplished in vitro and in vivo. BP-AuNPs also exhibit wonderful surface-enhanced Raman scattering (SERS) activity under NIR laser excitation with a low Raman background, allowing BP-AuNPs to be used as a promising two-dimensional (2D) fingerprint nanoprobe for bio-SERS analysis. The cellular component identification and label-free live-cell bioimaging based on this type of 2D SERS substrate are generally investigated, which open up promising new perspectives in nanomedicine, including diagnosis, imaging and therapy.

Original language	English (US)
Pages (from-to)	18795-18804
Number of pages	10
Journal	Nanoscale
Volume	10
Issue number	39
DOIs	https://doi.org/10.1039/c8nr05300f
State	Published - Oct 21 2018

ASJC Scopus subject areas

Materials Science(all)

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title = "A two-dimensional fingerprint nanoprobe based on black phosphorus for bio-SERS analysis and chemo-photothermal therapy",

abstract = "Flake-shaped nanohybrids based on black phosphorus (BP) have been developed as multifunctional theranostic nanoplatforms for drug delivery, phototherapy and bioimaging. In this work, we report a facile strategy for fabrication of black phosphorus-Au nanoparticle hybrids (BP-AuNPs), which reveal an extraordinary near-infrared (NIR) photothermal transduction efficiency and drug delivery capacity. The applications of the nanocomposites as therapeutic agents for high-performance chemo-photothermal tumor therapy are accomplished in vitro and in vivo. BP-AuNPs also exhibit wonderful surface-enhanced Raman scattering (SERS) activity under NIR laser excitation with a low Raman background, allowing BP-AuNPs to be used as a promising two-dimensional (2D) fingerprint nanoprobe for bio-SERS analysis. The cellular component identification and label-free live-cell bioimaging based on this type of 2D SERS substrate are generally investigated, which open up promising new perspectives in nanomedicine, including diagnosis, imaging and therapy.",

author = "Zhiming Liu and Haolin Chen and Yali Jia and Wen Zhang and Henan Zhao and Wendong Fan and Wolun Zhang and Huiqing Zhong and Yirong Ni and Zhouyi Guo",

note = "Funding Information: This work was supported by the National Natural Science Foundation of China (61335011, 61675072, 11874021, 21505047, 61505055, 61275187, 81500361 and 81670417), the Natural Science Foundation of Guangdong Province of China (2017A030313813 and 2014A030311024), the Science and Technology Project of Guangdong Province of China (2017A020215059) and the NIH grants (DP3 DK104397 and R01 EY024544). Publisher Copyright: {\textcopyright} 2018 The Royal Society of Chemistry.",

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doi = "10.1039/c8nr05300f",

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T1 - A two-dimensional fingerprint nanoprobe based on black phosphorus for bio-SERS analysis and chemo-photothermal therapy

AU - Liu, Zhiming

AU - Chen, Haolin

AU - Jia, Yali

AU - Zhang, Wen

AU - Zhao, Henan

AU - Fan, Wendong

AU - Zhang, Wolun

AU - Zhong, Huiqing

AU - Ni, Yirong

AU - Guo, Zhouyi

N1 - Funding Information: This work was supported by the National Natural Science Foundation of China (61335011, 61675072, 11874021, 21505047, 61505055, 61275187, 81500361 and 81670417), the Natural Science Foundation of Guangdong Province of China (2017A030313813 and 2014A030311024), the Science and Technology Project of Guangdong Province of China (2017A020215059) and the NIH grants (DP3 DK104397 and R01 EY024544). Publisher Copyright: © 2018 The Royal Society of Chemistry.

PY - 2018/10/21

Y1 - 2018/10/21

N2 - Flake-shaped nanohybrids based on black phosphorus (BP) have been developed as multifunctional theranostic nanoplatforms for drug delivery, phototherapy and bioimaging. In this work, we report a facile strategy for fabrication of black phosphorus-Au nanoparticle hybrids (BP-AuNPs), which reveal an extraordinary near-infrared (NIR) photothermal transduction efficiency and drug delivery capacity. The applications of the nanocomposites as therapeutic agents for high-performance chemo-photothermal tumor therapy are accomplished in vitro and in vivo. BP-AuNPs also exhibit wonderful surface-enhanced Raman scattering (SERS) activity under NIR laser excitation with a low Raman background, allowing BP-AuNPs to be used as a promising two-dimensional (2D) fingerprint nanoprobe for bio-SERS analysis. The cellular component identification and label-free live-cell bioimaging based on this type of 2D SERS substrate are generally investigated, which open up promising new perspectives in nanomedicine, including diagnosis, imaging and therapy.

AB - Flake-shaped nanohybrids based on black phosphorus (BP) have been developed as multifunctional theranostic nanoplatforms for drug delivery, phototherapy and bioimaging. In this work, we report a facile strategy for fabrication of black phosphorus-Au nanoparticle hybrids (BP-AuNPs), which reveal an extraordinary near-infrared (NIR) photothermal transduction efficiency and drug delivery capacity. The applications of the nanocomposites as therapeutic agents for high-performance chemo-photothermal tumor therapy are accomplished in vitro and in vivo. BP-AuNPs also exhibit wonderful surface-enhanced Raman scattering (SERS) activity under NIR laser excitation with a low Raman background, allowing BP-AuNPs to be used as a promising two-dimensional (2D) fingerprint nanoprobe for bio-SERS analysis. The cellular component identification and label-free live-cell bioimaging based on this type of 2D SERS substrate are generally investigated, which open up promising new perspectives in nanomedicine, including diagnosis, imaging and therapy.

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A two-dimensional fingerprint nanoprobe based on black phosphorus for bio-SERS analysis and chemo-photothermal therapy

Abstract

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