A two-dimensional fingerprint nanoprobe based on black phosphorus for bio-SERS analysis and chemo-photothermal therapy

Zhiming Liu, Haolin Chen, Jia Yali, Wen Zhang, Henan Zhao, Wendong Fan, Wolun Zhang, Huiqing Zhong, Yirong Ni, Zhouyi Guo

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Flake-shaped nanohybrids based on black phosphorus (BP) have been developed as multifunctional theranostic nanoplatforms for drug delivery, phototherapy and bioimaging. In this work, we report a facile strategy for fabrication of black phosphorus-Au nanoparticle hybrids (BP-AuNPs), which reveal an extraordinary near-infrared (NIR) photothermal transduction efficiency and drug delivery capacity. The applications of the nanocomposites as therapeutic agents for high-performance chemo-photothermal tumor therapy are accomplished in vitro and in vivo. BP-AuNPs also exhibit wonderful surface-enhanced Raman scattering (SERS) activity under NIR laser excitation with a low Raman background, allowing BP-AuNPs to be used as a promising two-dimensional (2D) fingerprint nanoprobe for bio-SERS analysis. The cellular component identification and label-free live-cell bioimaging based on this type of 2D SERS substrate are generally investigated, which open up promising new perspectives in nanomedicine, including diagnosis, imaging and therapy.

Original languageEnglish (US)
Pages (from-to)18795-18804
Number of pages10
JournalNanoscale
Volume10
Issue number39
DOIs
StatePublished - Oct 21 2018

Fingerprint

Nanoprobes
Chemotherapy
Phosphorus
Raman scattering
Drug delivery
Medical nanotechnology
Laser excitation
Infrared lasers
Labels
Tumors
Nanocomposites
Nanoparticles
Infrared radiation
Imaging techniques
Fabrication
Substrates

ASJC Scopus subject areas

  • Materials Science(all)

Cite this

A two-dimensional fingerprint nanoprobe based on black phosphorus for bio-SERS analysis and chemo-photothermal therapy. / Liu, Zhiming; Chen, Haolin; Yali, Jia; Zhang, Wen; Zhao, Henan; Fan, Wendong; Zhang, Wolun; Zhong, Huiqing; Ni, Yirong; Guo, Zhouyi.

In: Nanoscale, Vol. 10, No. 39, 21.10.2018, p. 18795-18804.

Research output: Contribution to journalArticle

Liu, Z, Chen, H, Yali, J, Zhang, W, Zhao, H, Fan, W, Zhang, W, Zhong, H, Ni, Y & Guo, Z 2018, 'A two-dimensional fingerprint nanoprobe based on black phosphorus for bio-SERS analysis and chemo-photothermal therapy', Nanoscale, vol. 10, no. 39, pp. 18795-18804. https://doi.org/10.1039/c8nr05300f
Liu, Zhiming ; Chen, Haolin ; Yali, Jia ; Zhang, Wen ; Zhao, Henan ; Fan, Wendong ; Zhang, Wolun ; Zhong, Huiqing ; Ni, Yirong ; Guo, Zhouyi. / A two-dimensional fingerprint nanoprobe based on black phosphorus for bio-SERS analysis and chemo-photothermal therapy. In: Nanoscale. 2018 ; Vol. 10, No. 39. pp. 18795-18804.
@article{8f8af2054c664c96afa2492f2b18e8e3,
title = "A two-dimensional fingerprint nanoprobe based on black phosphorus for bio-SERS analysis and chemo-photothermal therapy",
abstract = "Flake-shaped nanohybrids based on black phosphorus (BP) have been developed as multifunctional theranostic nanoplatforms for drug delivery, phototherapy and bioimaging. In this work, we report a facile strategy for fabrication of black phosphorus-Au nanoparticle hybrids (BP-AuNPs), which reveal an extraordinary near-infrared (NIR) photothermal transduction efficiency and drug delivery capacity. The applications of the nanocomposites as therapeutic agents for high-performance chemo-photothermal tumor therapy are accomplished in vitro and in vivo. BP-AuNPs also exhibit wonderful surface-enhanced Raman scattering (SERS) activity under NIR laser excitation with a low Raman background, allowing BP-AuNPs to be used as a promising two-dimensional (2D) fingerprint nanoprobe for bio-SERS analysis. The cellular component identification and label-free live-cell bioimaging based on this type of 2D SERS substrate are generally investigated, which open up promising new perspectives in nanomedicine, including diagnosis, imaging and therapy.",
author = "Zhiming Liu and Haolin Chen and Jia Yali and Wen Zhang and Henan Zhao and Wendong Fan and Wolun Zhang and Huiqing Zhong and Yirong Ni and Zhouyi Guo",
year = "2018",
month = "10",
day = "21",
doi = "10.1039/c8nr05300f",
language = "English (US)",
volume = "10",
pages = "18795--18804",
journal = "Nanoscale",
issn = "2040-3364",
publisher = "Royal Society of Chemistry",
number = "39",

}

TY - JOUR

T1 - A two-dimensional fingerprint nanoprobe based on black phosphorus for bio-SERS analysis and chemo-photothermal therapy

AU - Liu, Zhiming

AU - Chen, Haolin

AU - Yali, Jia

AU - Zhang, Wen

AU - Zhao, Henan

AU - Fan, Wendong

AU - Zhang, Wolun

AU - Zhong, Huiqing

AU - Ni, Yirong

AU - Guo, Zhouyi

PY - 2018/10/21

Y1 - 2018/10/21

N2 - Flake-shaped nanohybrids based on black phosphorus (BP) have been developed as multifunctional theranostic nanoplatforms for drug delivery, phototherapy and bioimaging. In this work, we report a facile strategy for fabrication of black phosphorus-Au nanoparticle hybrids (BP-AuNPs), which reveal an extraordinary near-infrared (NIR) photothermal transduction efficiency and drug delivery capacity. The applications of the nanocomposites as therapeutic agents for high-performance chemo-photothermal tumor therapy are accomplished in vitro and in vivo. BP-AuNPs also exhibit wonderful surface-enhanced Raman scattering (SERS) activity under NIR laser excitation with a low Raman background, allowing BP-AuNPs to be used as a promising two-dimensional (2D) fingerprint nanoprobe for bio-SERS analysis. The cellular component identification and label-free live-cell bioimaging based on this type of 2D SERS substrate are generally investigated, which open up promising new perspectives in nanomedicine, including diagnosis, imaging and therapy.

AB - Flake-shaped nanohybrids based on black phosphorus (BP) have been developed as multifunctional theranostic nanoplatforms for drug delivery, phototherapy and bioimaging. In this work, we report a facile strategy for fabrication of black phosphorus-Au nanoparticle hybrids (BP-AuNPs), which reveal an extraordinary near-infrared (NIR) photothermal transduction efficiency and drug delivery capacity. The applications of the nanocomposites as therapeutic agents for high-performance chemo-photothermal tumor therapy are accomplished in vitro and in vivo. BP-AuNPs also exhibit wonderful surface-enhanced Raman scattering (SERS) activity under NIR laser excitation with a low Raman background, allowing BP-AuNPs to be used as a promising two-dimensional (2D) fingerprint nanoprobe for bio-SERS analysis. The cellular component identification and label-free live-cell bioimaging based on this type of 2D SERS substrate are generally investigated, which open up promising new perspectives in nanomedicine, including diagnosis, imaging and therapy.

UR - http://www.scopus.com/inward/record.url?scp=85054926601&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85054926601&partnerID=8YFLogxK

U2 - 10.1039/c8nr05300f

DO - 10.1039/c8nr05300f

M3 - Article

C2 - 30277241

AN - SCOPUS:85054926601

VL - 10

SP - 18795

EP - 18804

JO - Nanoscale

JF - Nanoscale

SN - 2040-3364

IS - 39

ER -