A two-dimensional fingerprint nanoprobe based on black phosphorus for bio-SERS analysis and chemo-photothermal therapy

Zhiming Liu, Haolin Chen, Yali Jia, Wen Zhang, Henan Zhao, Wendong Fan, Wolun Zhang, Huiqing Zhong, Yirong Ni, Zhouyi Guo

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Flake-shaped nanohybrids based on black phosphorus (BP) have been developed as multifunctional theranostic nanoplatforms for drug delivery, phototherapy and bioimaging. In this work, we report a facile strategy for fabrication of black phosphorus-Au nanoparticle hybrids (BP-AuNPs), which reveal an extraordinary near-infrared (NIR) photothermal transduction efficiency and drug delivery capacity. The applications of the nanocomposites as therapeutic agents for high-performance chemo-photothermal tumor therapy are accomplished in vitro and in vivo. BP-AuNPs also exhibit wonderful surface-enhanced Raman scattering (SERS) activity under NIR laser excitation with a low Raman background, allowing BP-AuNPs to be used as a promising two-dimensional (2D) fingerprint nanoprobe for bio-SERS analysis. The cellular component identification and label-free live-cell bioimaging based on this type of 2D SERS substrate are generally investigated, which open up promising new perspectives in nanomedicine, including diagnosis, imaging and therapy.

Original languageEnglish (US)
Pages (from-to)18795-18804
Number of pages10
JournalNanoscale
Volume10
Issue number39
DOIs
StatePublished - Oct 21 2018

ASJC Scopus subject areas

  • Materials Science(all)

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    Liu, Z., Chen, H., Jia, Y., Zhang, W., Zhao, H., Fan, W., Zhang, W., Zhong, H., Ni, Y., & Guo, Z. (2018). A two-dimensional fingerprint nanoprobe based on black phosphorus for bio-SERS analysis and chemo-photothermal therapy. Nanoscale, 10(39), 18795-18804. https://doi.org/10.1039/c8nr05300f