A toxicologic and dermatologic assessment of cinnamyl phenylpropyl materials when used as fragrance ingredients

D. Belsito, D. Bickers, M. Bruze, P. Calow, M. Dagli, Allison Fryer, H. Greim, Y. Miyachi, J. H. Saurat, I. G. Sipes

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8 Scopus citations

Abstract

The cinnamyl phenylpropyl fragrance ingredients are a diverse group of chemical structures that have similar metabolic and toxicity profiles. A toxicological and dermatological review of these fragrance ingredients is presented. The common characteristic structural element of cinnamyl phenylpropyl materials is an aryl substituted primary alcohol/aldehyde/ester. For high end users, calculated maximum dermal exposures vary from 0.14% to 0.72%; systemic exposures vary from 0.0002 to 0.0280. mg/kg/day. Human dermatological studies show that these materials are not generally irritants or sensitizers at lower exposures from consumer products. Reactions (0.9%) in fragrance sensitive patients were observed with 3-phenyl-1-propanol at 5% in petrolatum. The cinnamyl phenylpropyl materials had low acute toxicity and no significant toxicity in repeat dose oral or dermal toxicity studies. No mutagenic or genotoxic activity in bacteria and mammalian cell line assays was observed. The cinnamyl phenylpropyl alcohol materials participate in the same beta oxidation pathways as their parent cinnamic acid derivatives, including common routes of absorption, distribution, and metabolic detoxification, and exhibit similar toxicological endpoints. Based on the review of available data, it is concluded that these materials would not present a safety concern at current levels of use as fragrance ingredients.

Original languageEnglish (US)
JournalFood and Chemical Toxicology
Volume49
Issue numberSUPPL. 2
DOIs
StatePublished - Dec 2011

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Keywords

  • Cinnamyl phenylpropyl
  • Fragrance ingredients
  • Review
  • Safety

ASJC Scopus subject areas

  • Food Science
  • Toxicology

Cite this

Belsito, D., Bickers, D., Bruze, M., Calow, P., Dagli, M., Fryer, A., Greim, H., Miyachi, Y., Saurat, J. H., & Sipes, I. G. (2011). A toxicologic and dermatologic assessment of cinnamyl phenylpropyl materials when used as fragrance ingredients. Food and Chemical Toxicology, 49(SUPPL. 2). https://doi.org/10.1016/j.fct.2011.07.053