A Time and a Place for Nkx2-1 in Interneuron Specification and Migration

Laura A B Elias, Gregory Potter, Arnold R. Kriegstein

13 Scopus citations

Abstract

The homeobox transcription factor, Nkx2-1, plays multiple roles during forebrain development. Using restricted genetic ablation of Nkx2-1, in this issue of Neuron, Butt et al. show that Nkx2-1 in telencephalic progenitors regulates interneuron subtype specification, while Nóbrega-Pereira et al. demonstrate that postmitotic Nkx2-1 regulates migration and sorting of interneurons to the striatum or cortex by controlling the expression of the guidance receptor, Neuropilin-2.

Original languageEnglish (US)
Pages (from-to)679-682
Number of pages4
JournalNeuron
Volume59
Issue number5
DOIs
Publication statusPublished - Sep 11 2008
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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