A Time and a Place for Nkx2-1 in Interneuron Specification and Migration

Laura A.B. Elias, Gregory B. Potter, Arnold R. Kriegstein

    Research output: Contribution to journalShort surveypeer-review

    14 Scopus citations

    Abstract

    The homeobox transcription factor, Nkx2-1, plays multiple roles during forebrain development. Using restricted genetic ablation of Nkx2-1, in this issue of Neuron, Butt et al. show that Nkx2-1 in telencephalic progenitors regulates interneuron subtype specification, while Nóbrega-Pereira et al. demonstrate that postmitotic Nkx2-1 regulates migration and sorting of interneurons to the striatum or cortex by controlling the expression of the guidance receptor, Neuropilin-2.

    Original languageEnglish (US)
    Pages (from-to)679-682
    Number of pages4
    JournalNeuron
    Volume59
    Issue number5
    DOIs
    StatePublished - Sep 11 2008

    ASJC Scopus subject areas

    • Neuroscience(all)

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