A therapeutic renaissance – emerging treatments for atopic dermatitis

Chan Ho Na, Wenelia Baghoomian, Eric L. Simpson

Research output: Contribution to journalArticlepeer-review

Abstract

Atopic dermatitis (AD) is a chronic, inflammatory cutaneous disease that is characterized by complex immune dysregulation and skin barrier dysfunction with a wide variety of clinical phenotypes. Until recently, conventional therapeutic modalities for AD remained rather non-specific despite AD’s complex etiology. Fai-ling to take into account the underlying inflammatory pathways led to treatments with inadequate efficacy or unacceptable long-term toxicities. We are currently in the midst of a therapeutic renaissance in AD. Recent progress in molecular medicine provides us a better understanding of the AD pathogenesis, suggesting a dominant helper T cell (Th) 2/Th22 response with a varying degree of Th1/Th17 overexpression. Targeted therapeutic agents including biologics and small molecule inhibitors in development hold promises for more effective and safer therapeutic approaches for AD. A better understanding of individual differences amongst AD patients will allow for a more tailored approach in the future. This review aims to cover the most promising emerging therapies in the field of atopic dermatitis utilizing recently published manuscripts and up-to-date conference abstracts and presentations.

Original languageEnglish (US)
Article numberadv00165
Pages (from-to)367-379
Number of pages13
JournalActa dermato-venereologica
Volume100
Issue number100-year theme Atopic dermatitis
DOIs
StatePublished - 2020

Keywords

  • Atopic dermatitis
  • Bio-logics
  • Small molecule inhibitors
  • Targeted therapeutic agents

ASJC Scopus subject areas

  • Dermatology

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