A systems framework for vaccine design

Michael Mooney, Shannon McWeeney, Glenda Canderan, Rafick Pierre Sékaly

Research output: Contribution to journalReview article

15 Scopus citations

Abstract

Numerous challenges have been identified in vaccine development, including variable efficacy as a function of population demographics and a lack of characterization and mechanistic understanding of immune correlates of protection able to guide delivery and dosing. There is tremendous opportunity in recent technological and computational advances to elucidate systems level understanding of pathogen–host interactions and correlates of immunity. A systems biology approach to vaccinology provides a new paradigm for rational vaccine design in a ‘precision medicine’ context.

Original languageEnglish (US)
Pages (from-to)551-555
Number of pages5
JournalCurrent opinion in immunology
Volume25
Issue number5
DOIs
StatePublished - Oct 1 2013

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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