A systematic review of the association between obstructive sleep apnea and ventricular arrhythmias

Akhil Raghuram, Ryan Clay, Anusha Kumbam, Larisa Tereshchenko, Akram Khan

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Introduction: Obstructive sleep apnea (OSA) is an independent risk factor for sudden cardiac death. The aim of this review was to study the relationship between OSA and ventricular arrhythmias. Methods: PubMed, Medline, and Cochrane databases were searched with MESH headings to find studies linking OSA and ventricular arrhythmias including ventricular ectopy, ventricular tachycardia (VT), and ventricular fibrillation (VF). Studies were graded by a scoring system, and an attempt was made to pool data. Results: There were no matched cohort or case control studies to study the association between OSA and ventricular arrhythmias. Given data heterogeneity, pooling and metaanalysis of data were not possible. An attempt was made to judge the quality of evidence and present a systematic review. Patients with OSA were noted to have higher odds of ventricular ectopy, and were at a higher risk for ventricular arrhythmias. Associations included higher QTc dispersion and HR variability. We did not, however, fi nd any clear evidence for a direct correlation between increased apnea hypopnea index and increased VT or VF. Conclusions: Pooling and meta-analysis of studies linking OSA and ventricular arrhythmias were not possible due to heterogeneity of data. In a systemic review of studies, patients with OSA were noted to have higher odds of ventricular ectopy and arrhythmias. A single study showed that CPAP may help lower arrhythmogenicity; however, it was unclear if CPAP lowered the risk of VT. Further research should focus on studying the association of OSA and causes of sudden cardiac death, including ventricular arrhythmias.

Original languageEnglish (US)
Pages (from-to)1155-1160
Number of pages6
JournalJournal of Clinical Sleep Medicine
Volume10
Issue number10
DOIs
StatePublished - 2014

Fingerprint

Obstructive Sleep Apnea
Cardiac Arrhythmias
Ventricular Tachycardia
Sudden Cardiac Death
Ventricular Fibrillation
Meta-Analysis
Apnea
PubMed
Case-Control Studies
Databases
Research

Keywords

  • Arrhythmia
  • OSA
  • Sleep apnea
  • Ventricular fibrillation
  • Ventricular tachycardia

ASJC Scopus subject areas

  • Clinical Neurology
  • Pulmonary and Respiratory Medicine
  • Neurology

Cite this

A systematic review of the association between obstructive sleep apnea and ventricular arrhythmias. / Raghuram, Akhil; Clay, Ryan; Kumbam, Anusha; Tereshchenko, Larisa; Khan, Akram.

In: Journal of Clinical Sleep Medicine, Vol. 10, No. 10, 2014, p. 1155-1160.

Research output: Contribution to journalArticle

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