Abstract
Introduction: Obstructive sleep apnea (OSA) is an independent risk factor for sudden cardiac death. The aim of this review was to study the relationship between OSA and ventricular arrhythmias. Methods: PubMed, Medline, and Cochrane databases were searched with MESH headings to find studies linking OSA and ventricular arrhythmias including ventricular ectopy, ventricular tachycardia (VT), and ventricular fibrillation (VF). Studies were graded by a scoring system, and an attempt was made to pool data. Results: There were no matched cohort or case control studies to study the association between OSA and ventricular arrhythmias. Given data heterogeneity, pooling and metaanalysis of data were not possible. An attempt was made to judge the quality of evidence and present a systematic review. Patients with OSA were noted to have higher odds of ventricular ectopy, and were at a higher risk for ventricular arrhythmias. Associations included higher QTc dispersion and HR variability. We did not, however, fi nd any clear evidence for a direct correlation between increased apnea hypopnea index and increased VT or VF. Conclusions: Pooling and meta-analysis of studies linking OSA and ventricular arrhythmias were not possible due to heterogeneity of data. In a systemic review of studies, patients with OSA were noted to have higher odds of ventricular ectopy and arrhythmias. A single study showed that CPAP may help lower arrhythmogenicity; however, it was unclear if CPAP lowered the risk of VT. Further research should focus on studying the association of OSA and causes of sudden cardiac death, including ventricular arrhythmias.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1155-1160 |
| Number of pages | 6 |
| Journal | Journal of Clinical Sleep Medicine |
| Volume | 10 |
| Issue number | 10 |
| DOIs | |
| State | Published - 2014 |
Fingerprint
Keywords
- Arrhythmia
- OSA
- Sleep apnea
- Ventricular fibrillation
- Ventricular tachycardia
ASJC Scopus subject areas
- Clinical Neurology
- Pulmonary and Respiratory Medicine
- Neurology
Cite this
A systematic review of the association between obstructive sleep apnea and ventricular arrhythmias. / Raghuram, Akhil; Clay, Ryan; Kumbam, Anusha; Tereshchenko, Larisa; Khan, Akram.
In: Journal of Clinical Sleep Medicine, Vol. 10, No. 10, 2014, p. 1155-1160.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A systematic review of the association between obstructive sleep apnea and ventricular arrhythmias
AU - Raghuram, Akhil
AU - Clay, Ryan
AU - Kumbam, Anusha
AU - Tereshchenko, Larisa
AU - Khan, Akram
PY - 2014
Y1 - 2014
N2 - Introduction: Obstructive sleep apnea (OSA) is an independent risk factor for sudden cardiac death. The aim of this review was to study the relationship between OSA and ventricular arrhythmias. Methods: PubMed, Medline, and Cochrane databases were searched with MESH headings to find studies linking OSA and ventricular arrhythmias including ventricular ectopy, ventricular tachycardia (VT), and ventricular fibrillation (VF). Studies were graded by a scoring system, and an attempt was made to pool data. Results: There were no matched cohort or case control studies to study the association between OSA and ventricular arrhythmias. Given data heterogeneity, pooling and metaanalysis of data were not possible. An attempt was made to judge the quality of evidence and present a systematic review. Patients with OSA were noted to have higher odds of ventricular ectopy, and were at a higher risk for ventricular arrhythmias. Associations included higher QTc dispersion and HR variability. We did not, however, fi nd any clear evidence for a direct correlation between increased apnea hypopnea index and increased VT or VF. Conclusions: Pooling and meta-analysis of studies linking OSA and ventricular arrhythmias were not possible due to heterogeneity of data. In a systemic review of studies, patients with OSA were noted to have higher odds of ventricular ectopy and arrhythmias. A single study showed that CPAP may help lower arrhythmogenicity; however, it was unclear if CPAP lowered the risk of VT. Further research should focus on studying the association of OSA and causes of sudden cardiac death, including ventricular arrhythmias.
AB - Introduction: Obstructive sleep apnea (OSA) is an independent risk factor for sudden cardiac death. The aim of this review was to study the relationship between OSA and ventricular arrhythmias. Methods: PubMed, Medline, and Cochrane databases were searched with MESH headings to find studies linking OSA and ventricular arrhythmias including ventricular ectopy, ventricular tachycardia (VT), and ventricular fibrillation (VF). Studies were graded by a scoring system, and an attempt was made to pool data. Results: There were no matched cohort or case control studies to study the association between OSA and ventricular arrhythmias. Given data heterogeneity, pooling and metaanalysis of data were not possible. An attempt was made to judge the quality of evidence and present a systematic review. Patients with OSA were noted to have higher odds of ventricular ectopy, and were at a higher risk for ventricular arrhythmias. Associations included higher QTc dispersion and HR variability. We did not, however, fi nd any clear evidence for a direct correlation between increased apnea hypopnea index and increased VT or VF. Conclusions: Pooling and meta-analysis of studies linking OSA and ventricular arrhythmias were not possible due to heterogeneity of data. In a systemic review of studies, patients with OSA were noted to have higher odds of ventricular ectopy and arrhythmias. A single study showed that CPAP may help lower arrhythmogenicity; however, it was unclear if CPAP lowered the risk of VT. Further research should focus on studying the association of OSA and causes of sudden cardiac death, including ventricular arrhythmias.
KW - Arrhythmia
KW - OSA
KW - Sleep apnea
KW - Ventricular fibrillation
KW - Ventricular tachycardia
UR - http://www.scopus.com/inward/record.url?scp=84908477344&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84908477344&partnerID=8YFLogxK
U2 - 10.5664/jcsm.4126
DO - 10.5664/jcsm.4126
M3 - Article
VL - 10
SP - 1155
EP - 1160
JO - Journal of Clinical Sleep Medicine
JF - Journal of Clinical Sleep Medicine
SN - 1550-9389
IS - 10
ER -