A surprising link between the energetics of ovariectomy-induced weight gain and mammary tumor progression in obese rats

Paul S. MacLean, Erin D. Giles, Ginger C. Johnson, Shauntae M. McDaniel, Brooke K. Fleming-Elder, Kaite A. Gilman, Anna G. Andrianakos, Matthew R. Jackman, Kenneth R. Shroyer, Pepper Schedin

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Obesity increases the risk for postmenopausal breast cancer. We have modeled this metabolic context using female Wistar rats that differ in their polygenic predisposition for obesity under conditions of high-fat feeding and limited physical activity. At 52 days of age, rats were injected with 1-methyl-1-nitrosourea (MNU, 50 mg/kg) and placed in an obesogenic environment. At 19 weeks of age, the rats were separated into lean, mid-weight, and obese rats, based upon their weight gained during this time. The rats were ovariectomized (OVX) at ∼24 weeks of age and the change in tumor multiplicity and burden, weight gain, energy intake, tumor estrogen receptor (ER) status, and humoral metabolite and cytokine profiles were examined. The survival and growth of tumors increased in obese rats in response to OVX. OVX induced a high rate of weight gain during post-OVX weeks 1-3, compared to SHAM-operated controls. During this time, feed efficiency (mg gain/kcal intake) was lower in obese rats, and this reduced storage efficiency of ingested fuels predicted the OVX-induced changes in tumor multiplicity (r = 0.64, P <0.001) and burden (r = 0.57, P

Original languageEnglish (US)
Pages (from-to)696-703
Number of pages8
JournalObesity
Volume18
Issue number4
DOIs
StatePublished - Apr 2010
Externally publishedYes

Fingerprint

Ovariectomy
Weight Gain
Breast Neoplasms
Obesity
Weights and Measures
Neoplasms
Energy Intake
Tumor Burden
Estrogen Receptors
Wistar Rats
Fats
Cytokines
Growth

ASJC Scopus subject areas

  • Endocrinology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

MacLean, P. S., Giles, E. D., Johnson, G. C., McDaniel, S. M., Fleming-Elder, B. K., Gilman, K. A., ... Schedin, P. (2010). A surprising link between the energetics of ovariectomy-induced weight gain and mammary tumor progression in obese rats. Obesity, 18(4), 696-703. https://doi.org/10.1038/oby.2009.307

A surprising link between the energetics of ovariectomy-induced weight gain and mammary tumor progression in obese rats. / MacLean, Paul S.; Giles, Erin D.; Johnson, Ginger C.; McDaniel, Shauntae M.; Fleming-Elder, Brooke K.; Gilman, Kaite A.; Andrianakos, Anna G.; Jackman, Matthew R.; Shroyer, Kenneth R.; Schedin, Pepper.

In: Obesity, Vol. 18, No. 4, 04.2010, p. 696-703.

Research output: Contribution to journalArticle

MacLean, PS, Giles, ED, Johnson, GC, McDaniel, SM, Fleming-Elder, BK, Gilman, KA, Andrianakos, AG, Jackman, MR, Shroyer, KR & Schedin, P 2010, 'A surprising link between the energetics of ovariectomy-induced weight gain and mammary tumor progression in obese rats', Obesity, vol. 18, no. 4, pp. 696-703. https://doi.org/10.1038/oby.2009.307
MacLean PS, Giles ED, Johnson GC, McDaniel SM, Fleming-Elder BK, Gilman KA et al. A surprising link between the energetics of ovariectomy-induced weight gain and mammary tumor progression in obese rats. Obesity. 2010 Apr;18(4):696-703. https://doi.org/10.1038/oby.2009.307
MacLean, Paul S. ; Giles, Erin D. ; Johnson, Ginger C. ; McDaniel, Shauntae M. ; Fleming-Elder, Brooke K. ; Gilman, Kaite A. ; Andrianakos, Anna G. ; Jackman, Matthew R. ; Shroyer, Kenneth R. ; Schedin, Pepper. / A surprising link between the energetics of ovariectomy-induced weight gain and mammary tumor progression in obese rats. In: Obesity. 2010 ; Vol. 18, No. 4. pp. 696-703.
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