A subclass of Ras proteins that regulate the degradation of IκB

Craig Fenwick, Soon Young Na, Reinhard E. Voll, Haihong Zhong, Suhn Young Im, Jae Lee, Sankar Ghosh

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Small guanosine triphosphatases, typified by the mammalian Ras proteins, play major roles in the regulation of numerous cellular pathways. A subclass of evolutionarily conserved Ras-like proteins was identified, members of which differ from other Ras proteins in containing amino acids at positions 12 and 61 that are similar to those present in the oncogenic forms of Ras. These proteins, κB-Ras1 and κB-Ras2, interact with the PEST domains of IκBα and IκBβ [inhibitors of the transcription factor nuclear factor kappa B (NF-κB)] and decrease their rate of degradation. In cells, κB-Ras proteins are associated only with NF-κB:IκBβ complexes and therefore may provide an explanation for the slower rate of degradation of IκBβ compared with IκBα.

Original languageEnglish (US)
Pages (from-to)869-873
Number of pages5
JournalScience
Volume287
Issue number5454
DOIs
StatePublished - Feb 4 2000
Externally publishedYes

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ras Proteins
Proteolysis
NF-kappa B
Guanosine
Transcription Factors
Amino Acids

ASJC Scopus subject areas

  • General

Cite this

Fenwick, C., Na, S. Y., Voll, R. E., Zhong, H., Im, S. Y., Lee, J., & Ghosh, S. (2000). A subclass of Ras proteins that regulate the degradation of IκB. Science, 287(5454), 869-873. https://doi.org/10.1126/science.287.5454.869

A subclass of Ras proteins that regulate the degradation of IκB. / Fenwick, Craig; Na, Soon Young; Voll, Reinhard E.; Zhong, Haihong; Im, Suhn Young; Lee, Jae; Ghosh, Sankar.

In: Science, Vol. 287, No. 5454, 04.02.2000, p. 869-873.

Research output: Contribution to journalArticle

Fenwick, C, Na, SY, Voll, RE, Zhong, H, Im, SY, Lee, J & Ghosh, S 2000, 'A subclass of Ras proteins that regulate the degradation of IκB', Science, vol. 287, no. 5454, pp. 869-873. https://doi.org/10.1126/science.287.5454.869
Fenwick C, Na SY, Voll RE, Zhong H, Im SY, Lee J et al. A subclass of Ras proteins that regulate the degradation of IκB. Science. 2000 Feb 4;287(5454):869-873. https://doi.org/10.1126/science.287.5454.869
Fenwick, Craig ; Na, Soon Young ; Voll, Reinhard E. ; Zhong, Haihong ; Im, Suhn Young ; Lee, Jae ; Ghosh, Sankar. / A subclass of Ras proteins that regulate the degradation of IκB. In: Science. 2000 ; Vol. 287, No. 5454. pp. 869-873.
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