A standardized method for collection of human placenta samples in the age of functional magnetic resonance imaging

Victoria H.J. Roberts, Jessica E. Gaffney, Katherine S. Lewandowski, Matthias C. Schabel, Terry K. Morgan, Antonio E. Frias

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Current methods for placental tissue collection assess a delivered organ without direct functional correlates; therefore, the four-quadrant biopsy protocol utilized by many researchers may provide reasonable representation of tissue across a large organ, and offer a snapshot for molecular analysis of the placenta. However, the recent impetus to understand the placenta in real time, and the use of functional imaging to comprehend placental biology, warrants a different sampling approach. Here we present a method to standardize placental tissue collection in a format designed to facilitate correlation of in vivo function with ex vivo assessments. Additionally, we draw comparisons to the quadrant biopsy regimen, and highlight a pathological case of placental infarction detected by in utero imaging.

Original languageEnglish (US)
Pages (from-to)45-49
Number of pages5
JournalBioTechniques
Volume67
Issue number2
DOIs
StatePublished - 2019

Keywords

  • Biopsy
  • Placenta
  • Standardized sampling

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry, Genetics and Molecular Biology(all)

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