A Spectrum of Bilateral Squamous Conjunctival Tumors Associated with Human Papillomavirus Type 16

Marl G. Odrich, Frederick A. Jakobiec, Wayne D. Lancaster, Kenneth R. Kenyon, Lisa D. Kelly, Ernest W. Kornmehl, Roger F. Steinert, Arthur S. Grove, John W. Shore, Lucie Gregoire, Daniel Albert

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Three patients with bilateral tumors presenting as multiple keratinizing and verrucous lesions of the bulbar and tarsal conjunctiva were determined by DNA amplification and hybridization studies to harbor human papillomavirus type 16 (HPV-16). Results of biopsy in two patients showed infiltrating squamous cell carcinoma in one eye and dysplasia or carcinoma in situ in the fellow eye. In the third patient, focal, inflamed, hypertrophic, papillary lesions with pseudoglandular invaginations of the surface epithelium were found in the tarsal conjunctivae of both eyes. These are the first documented cases of bilateral conjunctival tumors associated with human papillomavirus.

Original languageEnglish (US)
Pages (from-to)628-635
Number of pages8
JournalOphthalmology
Volume98
Issue number5
DOIs
StatePublished - Jan 1 1991
Externally publishedYes

Fingerprint

Human papillomavirus 16
Conjunctiva
Neoplasms
Carcinoma in Situ
Squamous Cell Carcinoma
Epithelium
Biopsy
DNA

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Odrich, M. G., Jakobiec, F. A., Lancaster, W. D., Kenyon, K. R., Kelly, L. D., Kornmehl, E. W., ... Albert, D. (1991). A Spectrum of Bilateral Squamous Conjunctival Tumors Associated with Human Papillomavirus Type 16. Ophthalmology, 98(5), 628-635. https://doi.org/10.1016/S0161-6420(91)32218-8

A Spectrum of Bilateral Squamous Conjunctival Tumors Associated with Human Papillomavirus Type 16. / Odrich, Marl G.; Jakobiec, Frederick A.; Lancaster, Wayne D.; Kenyon, Kenneth R.; Kelly, Lisa D.; Kornmehl, Ernest W.; Steinert, Roger F.; Grove, Arthur S.; Shore, John W.; Gregoire, Lucie; Albert, Daniel.

In: Ophthalmology, Vol. 98, No. 5, 01.01.1991, p. 628-635.

Research output: Contribution to journalArticle

Odrich, MG, Jakobiec, FA, Lancaster, WD, Kenyon, KR, Kelly, LD, Kornmehl, EW, Steinert, RF, Grove, AS, Shore, JW, Gregoire, L & Albert, D 1991, 'A Spectrum of Bilateral Squamous Conjunctival Tumors Associated with Human Papillomavirus Type 16', Ophthalmology, vol. 98, no. 5, pp. 628-635. https://doi.org/10.1016/S0161-6420(91)32218-8
Odrich MG, Jakobiec FA, Lancaster WD, Kenyon KR, Kelly LD, Kornmehl EW et al. A Spectrum of Bilateral Squamous Conjunctival Tumors Associated with Human Papillomavirus Type 16. Ophthalmology. 1991 Jan 1;98(5):628-635. https://doi.org/10.1016/S0161-6420(91)32218-8
Odrich, Marl G. ; Jakobiec, Frederick A. ; Lancaster, Wayne D. ; Kenyon, Kenneth R. ; Kelly, Lisa D. ; Kornmehl, Ernest W. ; Steinert, Roger F. ; Grove, Arthur S. ; Shore, John W. ; Gregoire, Lucie ; Albert, Daniel. / A Spectrum of Bilateral Squamous Conjunctival Tumors Associated with Human Papillomavirus Type 16. In: Ophthalmology. 1991 ; Vol. 98, No. 5. pp. 628-635.
@article{3260f8c41fc34b83bf8069424fc0220d,
title = "A Spectrum of Bilateral Squamous Conjunctival Tumors Associated with Human Papillomavirus Type 16",
abstract = "Three patients with bilateral tumors presenting as multiple keratinizing and verrucous lesions of the bulbar and tarsal conjunctiva were determined by DNA amplification and hybridization studies to harbor human papillomavirus type 16 (HPV-16). Results of biopsy in two patients showed infiltrating squamous cell carcinoma in one eye and dysplasia or carcinoma in situ in the fellow eye. In the third patient, focal, inflamed, hypertrophic, papillary lesions with pseudoglandular invaginations of the surface epithelium were found in the tarsal conjunctivae of both eyes. These are the first documented cases of bilateral conjunctival tumors associated with human papillomavirus.",
author = "Odrich, {Marl G.} and Jakobiec, {Frederick A.} and Lancaster, {Wayne D.} and Kenyon, {Kenneth R.} and Kelly, {Lisa D.} and Kornmehl, {Ernest W.} and Steinert, {Roger F.} and Grove, {Arthur S.} and Shore, {John W.} and Lucie Gregoire and Daniel Albert",
year = "1991",
month = "1",
day = "1",
doi = "10.1016/S0161-6420(91)32218-8",
language = "English (US)",
volume = "98",
pages = "628--635",
journal = "Ophthalmology",
issn = "0161-6420",
publisher = "Elsevier Inc.",
number = "5",

}

TY - JOUR

T1 - A Spectrum of Bilateral Squamous Conjunctival Tumors Associated with Human Papillomavirus Type 16

AU - Odrich, Marl G.

AU - Jakobiec, Frederick A.

AU - Lancaster, Wayne D.

AU - Kenyon, Kenneth R.

AU - Kelly, Lisa D.

AU - Kornmehl, Ernest W.

AU - Steinert, Roger F.

AU - Grove, Arthur S.

AU - Shore, John W.

AU - Gregoire, Lucie

AU - Albert, Daniel

PY - 1991/1/1

Y1 - 1991/1/1

N2 - Three patients with bilateral tumors presenting as multiple keratinizing and verrucous lesions of the bulbar and tarsal conjunctiva were determined by DNA amplification and hybridization studies to harbor human papillomavirus type 16 (HPV-16). Results of biopsy in two patients showed infiltrating squamous cell carcinoma in one eye and dysplasia or carcinoma in situ in the fellow eye. In the third patient, focal, inflamed, hypertrophic, papillary lesions with pseudoglandular invaginations of the surface epithelium were found in the tarsal conjunctivae of both eyes. These are the first documented cases of bilateral conjunctival tumors associated with human papillomavirus.

AB - Three patients with bilateral tumors presenting as multiple keratinizing and verrucous lesions of the bulbar and tarsal conjunctiva were determined by DNA amplification and hybridization studies to harbor human papillomavirus type 16 (HPV-16). Results of biopsy in two patients showed infiltrating squamous cell carcinoma in one eye and dysplasia or carcinoma in situ in the fellow eye. In the third patient, focal, inflamed, hypertrophic, papillary lesions with pseudoglandular invaginations of the surface epithelium were found in the tarsal conjunctivae of both eyes. These are the first documented cases of bilateral conjunctival tumors associated with human papillomavirus.

UR - http://www.scopus.com/inward/record.url?scp=0025765956&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025765956&partnerID=8YFLogxK

U2 - 10.1016/S0161-6420(91)32218-8

DO - 10.1016/S0161-6420(91)32218-8

M3 - Article

C2 - 1648188

AN - SCOPUS:0025765956

VL - 98

SP - 628

EP - 635

JO - Ophthalmology

JF - Ophthalmology

SN - 0161-6420

IS - 5

ER -