Abstract
(Chemical Equation Presented) Watching live: The FRET reporter PENN/SATE (see picture; FRET = fluorescence resonance energy transfer) is membrane permeant and enters cells and small organisms by using a prodrug approach. Once inside cells the reporter is cleaved by phospholipases, which results in a 30-fold change in the emission ratio.
Original language | English (US) |
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Pages (from-to) | 508-512 |
Number of pages | 5 |
Journal | Angewandte Chemie - International Edition |
Volume | 45 |
Issue number | 3 |
DOIs | |
State | Published - Jan 9 2006 |
Externally published | Yes |
Keywords
- Bioorganic chemistry
- FRET (fluorescence resonance energy transfer)
- Fluorescent probes
- Phospholipids
- Signal transduction
ASJC Scopus subject areas
- Catalysis
- General Chemistry