A single tablet regimen is associated with higher adherence and viral suppression than multiple tablet regimens in HIV+ homeless and marginally housed people

David R. Bangsberg, Kathleen Ragland, Alex Monk, Steven G. Deeks

Research output: Contribution to journalArticle

135 Scopus citations

Abstract

Background: Although, single-tablet regimen (STR) efavirenz, emtricibine, and tenofovir disoproxil fumarate (EFV/FTC/TDF) may be appealing in HIV-infected persons who are at high risk for nonadherence, the degree to which this simplified formulation affects adherence is not known. The virologic effectiveness of this STR in a potentially nonadherent population remains a concern, given the rapid selection of drug resistance seen with these drugs. Method: We performed a prospective observational study assessing adherence and virologic response to EFV/FTC/TDF STR among a cohort of homeless and marginally housed individuals. We compared adherence and viral suppression to historical controls followed in the same cohort. Results: Adherence was higher in EFV/FTC/TDF STR regimen compared to non-onepill- once-daily therapy (P=0.006) after controlling for multiple confounders. Viral suppression (HIV RNA <50 copies/ml) was greater in EFV/ FTC/TDF STR than non-onepill- once-daily regimens (69.2 versus 46.5%; P=0.02), but there was no difference in viral suppression after controlling for adherence. Conclusion: Once-daily EFV/TNF/FTC STR appears to be a reasonable option for individuals with multiple barriers to adherence. Randomized clinical trials addressing various therapeutic strategies for this patient population are needed.

Original languageEnglish (US)
Pages (from-to)2835-2840
Number of pages6
JournalAIDS
Volume24
Issue number18
DOIs
StatePublished - Nov 27 2010
Externally publishedYes

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Keywords

  • Adherence
  • Dosing frequency
  • Drug use
  • Homeless
  • Mental illness
  • Once daily
  • One pill
  • Pill-burden

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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