A single-dose cytomegalovirus-based vaccine encoding tetanus toxin fragment C induces sustained levels of protective tetanus toxin antibodies in mice

Rob Tierney, Toru Nakai, Christopher J. Parkins, Patrizia Caposio, Neil F. Fairweather, Dorothea Sesardic, Michael A. Jarvis

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

The current commercially available vaccine used to prevent tetanus disease following infection with the anaerobic bacterium . Clostridium tetani is safe and effective. However, tetanus remains a major source of mortality in developing countries. In 2008, neonatal tetanus was estimated to have caused >59,000 deaths, accounting for 1% of worldwide infant mortality, primarily in poorer nations. The cost of multiple vaccine doses administered by injection necessary to achieve protective levels of anti-tetanus toxoid antibodies is the primary reason for low vaccine coverage. Herein, we show that a novel vaccine strategy using a cytomegalovirus (CMV)-based vaccine platform induces protective levels of anti-tetanus antibodies that are durable (lasting >13 months) in mice following only a single dose. This study demonstrates the ability of a 'single-dose' CMV-based vaccine strategy to induce durable protection, and supports the potential for a tetanus vaccine based on CMV to impact the incidence of tetanus in developing countries.

Original languageEnglish (US)
Pages (from-to)3047-3052
Number of pages6
JournalVaccine
Volume30
Issue number20
DOIs
StatePublished - Apr 26 2012

Keywords

  • Antibody
  • Cytomegalovirus-based vaccine
  • Mice
  • Neglected tropical disease
  • Tetanus

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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