A simian hemorrhagic fever virus isolate from persistently infected baboons efficiently induces hemorrhagic fever disease in Japanese macaques

Heather A. Vatter, Eric F. Donaldson, Jeremy Huynh, Stephanie Rawlings, Minsha Manoharan, Alfred Legasse, Shannon Planer, Mary F. Dickerson, Anne Lewis, Lois Colgin, Michael Axthelm, Jerilyn K. Pecotte, Ralph S. Baric, Scott Wong, Margo A. Brinton

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Simian hemorrhagic fever virus is an arterivirus that naturally infects species of African nonhuman primates causing acute or persistent asymptomatic infections. Although it was previously estimated that 1% of baboons are SHFV-positive, more than 10% of wild-caught and captive-bred baboons tested were SHFV positive and the infections persisted for more than 10 years with detectable virus in the blood (100-1000 genomes/ml). The sequences of two baboon SHFV isolates that were amplified by a single passage in primary macaque macrophages had a high degree of identity to each other as well as to the genome of SHFV-LVR, a laboratory strain isolated in the 1960s. Infection of Japanese macaques with 100. PFU of a baboon isolate consistently produced high level viremia, pro-inflammatory cytokines, elevated tissue factor levels and clinical signs indicating coagulation defects. The baboon virus isolate provides a reliable BSL2 model of viral hemorrhagic fever disease in macaques.

Original languageEnglish (US)
Pages (from-to)186-198
Number of pages13
JournalVirology
Volume474
DOIs
StatePublished - Jan 1 2015

Fingerprint

Arterivirus
Papio
Macaca
Fever
Viral Hemorrhagic Fevers
Genome
Viruses
Asymptomatic Infections
Viremia
Thromboplastin
Infection
Primates
Macrophages
Cytokines

Keywords

  • Baboon
  • Coagulopathy
  • Hemorrhagic fever disease
  • Japanese macaque
  • Persistent infection
  • Simian hemorrhagic fever virus

ASJC Scopus subject areas

  • Virology

Cite this

Vatter, H. A., Donaldson, E. F., Huynh, J., Rawlings, S., Manoharan, M., Legasse, A., ... Brinton, M. A. (2015). A simian hemorrhagic fever virus isolate from persistently infected baboons efficiently induces hemorrhagic fever disease in Japanese macaques. Virology, 474, 186-198. https://doi.org/10.1016/j.virol.2014.10.018

A simian hemorrhagic fever virus isolate from persistently infected baboons efficiently induces hemorrhagic fever disease in Japanese macaques. / Vatter, Heather A.; Donaldson, Eric F.; Huynh, Jeremy; Rawlings, Stephanie; Manoharan, Minsha; Legasse, Alfred; Planer, Shannon; Dickerson, Mary F.; Lewis, Anne; Colgin, Lois; Axthelm, Michael; Pecotte, Jerilyn K.; Baric, Ralph S.; Wong, Scott; Brinton, Margo A.

In: Virology, Vol. 474, 01.01.2015, p. 186-198.

Research output: Contribution to journalArticle

Vatter, HA, Donaldson, EF, Huynh, J, Rawlings, S, Manoharan, M, Legasse, A, Planer, S, Dickerson, MF, Lewis, A, Colgin, L, Axthelm, M, Pecotte, JK, Baric, RS, Wong, S & Brinton, MA 2015, 'A simian hemorrhagic fever virus isolate from persistently infected baboons efficiently induces hemorrhagic fever disease in Japanese macaques', Virology, vol. 474, pp. 186-198. https://doi.org/10.1016/j.virol.2014.10.018
Vatter, Heather A. ; Donaldson, Eric F. ; Huynh, Jeremy ; Rawlings, Stephanie ; Manoharan, Minsha ; Legasse, Alfred ; Planer, Shannon ; Dickerson, Mary F. ; Lewis, Anne ; Colgin, Lois ; Axthelm, Michael ; Pecotte, Jerilyn K. ; Baric, Ralph S. ; Wong, Scott ; Brinton, Margo A. / A simian hemorrhagic fever virus isolate from persistently infected baboons efficiently induces hemorrhagic fever disease in Japanese macaques. In: Virology. 2015 ; Vol. 474. pp. 186-198.
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