A side-by-side comparison of T cell reactivity to fifty-nine Mycobacterium tuberculosis antigens in diverse populations from five continents

Chelsea Carpenter, John Sidney, Ravi Kolla, Kaustuv Nayak, Helena Tomiyama, Claudia Tomiyama, Oscar A. Padilla, Virginie Rozot, Syed F. Ahamed, Carlos Ponte, Valeria Rolla, Paulo R. Antas, Anmol Chandele, John Kenneth, Seetha Laxmi, Edward Makgotlho, Valentina Vanini, Giuseppe Ippolito, Alexandra S. Kazanova, Alexander V. PanteleevWillem Hanekom, Harriet Mayanja-Kizza, David Lewinsohn, Mayuko Saito, M. Juliana McElrath, W. Henry Boom, Delia Goletti, Robert Gilman, Irina V. Lyadova, Thomas J. Scriba, Esper G. Kallas, Kaja Murali-Krishna, Alessandro Sette, Cecilia S. Lindestam Arlehamn

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

We compared T cell recognition of 59 prevalently recognized Mycobacterium tuberculosis (MTB) antigens in individuals latently infected with MTB (LTBI), and uninfected individuals with previous BCG vaccination, from nine locations and populations with different HLA distribution, MTB exposure rates, and standards of TB care. This comparison revealed similar response magnitudes in diverse LTBI and BCG-vaccinated cohorts and significant correlation between responses in LTBIs from the USA and other locations. Many antigens were uniformly recognized, suggesting suitability for inclusion in vaccines targeting diverse populations. Several antigens were similarly immunodominant in LTBI and BCG cohorts, suggesting applicability for vaccines aimed at boosting BCG responses. The panel of MTB antigens will be valuable for characterizing MTB-specific CD4 T cell responses irrespective of ethnicity, infecting MTB strains and BCG vaccination status. Our results illustrate how a comparative analysis can provide insight into the relative immunogenicity of existing and novel vaccine candidates in LTBIs.

Original languageEnglish (US)
Pages (from-to)713-721
Number of pages9
JournalTuberculosis
Volume95
Issue number6
DOIs
StatePublished - Dec 1 2015

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Mycobacterium bovis
Mycobacterium tuberculosis
T-Lymphocytes
Vaccines
Population
Vaccination
Antigens
Standard of Care
Mycobacterium tuberculosis antigens

Keywords

  • BCG
  • CD4
  • LTBI
  • T cell antigen
  • Tuberculosis
  • Vaccine

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Infectious Diseases
  • Microbiology (medical)

Cite this

Carpenter, C., Sidney, J., Kolla, R., Nayak, K., Tomiyama, H., Tomiyama, C., ... Lindestam Arlehamn, C. S. (2015). A side-by-side comparison of T cell reactivity to fifty-nine Mycobacterium tuberculosis antigens in diverse populations from five continents. Tuberculosis, 95(6), 713-721. https://doi.org/10.1016/j.tube.2015.07.001

A side-by-side comparison of T cell reactivity to fifty-nine Mycobacterium tuberculosis antigens in diverse populations from five continents. / Carpenter, Chelsea; Sidney, John; Kolla, Ravi; Nayak, Kaustuv; Tomiyama, Helena; Tomiyama, Claudia; Padilla, Oscar A.; Rozot, Virginie; Ahamed, Syed F.; Ponte, Carlos; Rolla, Valeria; Antas, Paulo R.; Chandele, Anmol; Kenneth, John; Laxmi, Seetha; Makgotlho, Edward; Vanini, Valentina; Ippolito, Giuseppe; Kazanova, Alexandra S.; Panteleev, Alexander V.; Hanekom, Willem; Mayanja-Kizza, Harriet; Lewinsohn, David; Saito, Mayuko; McElrath, M. Juliana; Boom, W. Henry; Goletti, Delia; Gilman, Robert; Lyadova, Irina V.; Scriba, Thomas J.; Kallas, Esper G.; Murali-Krishna, Kaja; Sette, Alessandro; Lindestam Arlehamn, Cecilia S.

In: Tuberculosis, Vol. 95, No. 6, 01.12.2015, p. 713-721.

Research output: Contribution to journalArticle

Carpenter, C, Sidney, J, Kolla, R, Nayak, K, Tomiyama, H, Tomiyama, C, Padilla, OA, Rozot, V, Ahamed, SF, Ponte, C, Rolla, V, Antas, PR, Chandele, A, Kenneth, J, Laxmi, S, Makgotlho, E, Vanini, V, Ippolito, G, Kazanova, AS, Panteleev, AV, Hanekom, W, Mayanja-Kizza, H, Lewinsohn, D, Saito, M, McElrath, MJ, Boom, WH, Goletti, D, Gilman, R, Lyadova, IV, Scriba, TJ, Kallas, EG, Murali-Krishna, K, Sette, A & Lindestam Arlehamn, CS 2015, 'A side-by-side comparison of T cell reactivity to fifty-nine Mycobacterium tuberculosis antigens in diverse populations from five continents', Tuberculosis, vol. 95, no. 6, pp. 713-721. https://doi.org/10.1016/j.tube.2015.07.001
Carpenter, Chelsea ; Sidney, John ; Kolla, Ravi ; Nayak, Kaustuv ; Tomiyama, Helena ; Tomiyama, Claudia ; Padilla, Oscar A. ; Rozot, Virginie ; Ahamed, Syed F. ; Ponte, Carlos ; Rolla, Valeria ; Antas, Paulo R. ; Chandele, Anmol ; Kenneth, John ; Laxmi, Seetha ; Makgotlho, Edward ; Vanini, Valentina ; Ippolito, Giuseppe ; Kazanova, Alexandra S. ; Panteleev, Alexander V. ; Hanekom, Willem ; Mayanja-Kizza, Harriet ; Lewinsohn, David ; Saito, Mayuko ; McElrath, M. Juliana ; Boom, W. Henry ; Goletti, Delia ; Gilman, Robert ; Lyadova, Irina V. ; Scriba, Thomas J. ; Kallas, Esper G. ; Murali-Krishna, Kaja ; Sette, Alessandro ; Lindestam Arlehamn, Cecilia S. / A side-by-side comparison of T cell reactivity to fifty-nine Mycobacterium tuberculosis antigens in diverse populations from five continents. In: Tuberculosis. 2015 ; Vol. 95, No. 6. pp. 713-721.
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AU - Kolla, Ravi

AU - Nayak, Kaustuv

AU - Tomiyama, Helena

AU - Tomiyama, Claudia

AU - Padilla, Oscar A.

AU - Rozot, Virginie

AU - Ahamed, Syed F.

AU - Ponte, Carlos

AU - Rolla, Valeria

AU - Antas, Paulo R.

AU - Chandele, Anmol

AU - Kenneth, John

AU - Laxmi, Seetha

AU - Makgotlho, Edward

AU - Vanini, Valentina

AU - Ippolito, Giuseppe

AU - Kazanova, Alexandra S.

AU - Panteleev, Alexander V.

AU - Hanekom, Willem

AU - Mayanja-Kizza, Harriet

AU - Lewinsohn, David

AU - Saito, Mayuko

AU - McElrath, M. Juliana

AU - Boom, W. Henry

AU - Goletti, Delia

AU - Gilman, Robert

AU - Lyadova, Irina V.

AU - Scriba, Thomas J.

AU - Kallas, Esper G.

AU - Murali-Krishna, Kaja

AU - Sette, Alessandro

AU - Lindestam Arlehamn, Cecilia S.

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